PTPLAD2 [The Human Chemical-Genetic Interaction Map Project]

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======= PTPLAD2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HACD4
  * **<color #00a2e8>Official Name</color>**: 3-hydroxyacyl-CoA dehydratase 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=401494|401494]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5VWC8|Q5VWC8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PTPLAD2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PTPLAD2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615941|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the third of the four reactions of the long- chain fatty acids elongation cycle. This endoplasmic reticulum- bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000269|PubMed:18554506}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PTPLA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|3-hydroxy-behenoyl-CoA dehydratase activity|
|3-hydroxy-lignoceroyl-CoA dehydratase activity|
|3-hydroxy-arachidoyl-CoA dehydratase activity|
|very-long-chain 3-hydroxyacyl-CoA dehydratase activity|
|3-hydroxyacyl-CoA dehydratase activity|
|fatty acid elongation|
|very long-chain fatty acid biosynthetic process|
|very long-chain fatty acid metabolic process|
|sphingolipid biosynthetic process|
|fatty acid biosynthetic process|
|membrane lipid biosynthetic process|
|sphingolipid metabolic process|
|monocarboxylic acid biosynthetic process|
|membrane lipid metabolic process|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|fatty acid metabolic process|
|enzyme binding|
|monocarboxylic acid metabolic process|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|carboxylic acid metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|oxoacid metabolic process|
|endoplasmic reticulum|
|organic acid metabolic process|
|lipid metabolic process|
|organonitrogen compound biosynthetic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp124|GSK343 3μM R03 exp124]]|1.72|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|1.88|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|2.05|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.08|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|2.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18995
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.5 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PTPLAD2 Expression in NALM6 Cells: 2.5'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>