PTPLAD2

Entrez Summary: N/A
UniProt Summary: Catalyzes the third of the four reactions of the long- chain fatty acids elongation cycle. This endoplasmic reticulum- bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000269|PubMed:18554506}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

3-hydroxy-behenoyl-CoA dehydratase activity
3-hydroxy-lignoceroyl-CoA dehydratase activity
3-hydroxy-arachidoyl-CoA dehydratase activity
very-long-chain 3-hydroxyacyl-CoA dehydratase activity
3-hydroxyacyl-CoA dehydratase activity
fatty acid elongation
very long-chain fatty acid biosynthetic process
very long-chain fatty acid metabolic process
sphingolipid biosynthetic process
fatty acid biosynthetic process
membrane lipid biosynthetic process
sphingolipid metabolic process
monocarboxylic acid biosynthetic process
membrane lipid metabolic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
fatty acid metabolic process
enzyme binding
monocarboxylic acid metabolic process
lipid biosynthetic process
small molecule biosynthetic process
carboxylic acid metabolic process
endoplasmic reticulum membrane
cellular lipid metabolic process
oxoacid metabolic process
endoplasmic reticulum
organic acid metabolic process
lipid metabolic process
organonitrogen compound biosynthetic process
small molecule metabolic process