PTPN11 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= PTPN11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PTPN11
  * **<color #00a2e8>Official Name</color>**: protein tyrosine phosphatase non-receptor type 11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5781|5781]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q06124|Q06124]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PTPN11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PTPN11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/176876|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway (PubMed:28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73 (PubMed:26742426). {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:18559669, ECO:0000269|PubMed:18829466, ECO:0000269|PubMed:26742426, ECO:0000269|PubMed:28074573}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Y phosphatase|
|SH2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of cortisol secretion|
|intestinal epithelial cell migration|
|negative regulation of steroid hormone secretion|
|negative regulation of growth hormone secretion|
|negative regulation of glucocorticoid secretion|
|abortive mitotic cell cycle|
|negative regulation of corticosteroid hormone secretion|
|regulation of cortisol secretion|
|atrioventricular canal development|
|Bergmann glial cell differentiation|
|non-membrane spanning protein tyrosine phosphatase activity|
|D1 dopamine receptor binding|
|regulation of glucocorticoid secretion|
|peptide hormone receptor binding|
|insulin receptor substrate binding|
|negative regulation of cell adhesion mediated by integrin|
|regulation of growth hormone secretion|
|regulation of corticosteroid hormone secretion|
|phospholipase binding|
|interleukin-6-mediated signaling pathway|
|megakaryocyte development|
|platelet formation|
|regulation of steroid hormone secretion|
|microvillus organization|
|platelet morphogenesis|
|neurotrophin TRK receptor signaling pathway|
|cerebellar cortex formation|
|megakaryocyte differentiation|
|positive regulation of insulin receptor signaling pathway|
|insulin receptor binding|
|positive regulation of cellular response to insulin stimulus|
|bone cell development|
|negative regulation of lipid transport|
|negative regulation of response to drug|
|neurotrophin signaling pathway|
|homeostasis of number of cells within a tissue|
|cerebellar cortex morphogenesis|
|positive regulation of interferon-beta production|
|face morphogenesis|
|cellular response to interleukin-6|
|platelet-derived growth factor receptor signaling pathway|
|regulation of type I interferon-mediated signaling pathway|
|response to interleukin-6|
|positive regulation of glucose import|
|head morphogenesis|
|cerebellum morphogenesis|
|negative regulation of insulin secretion|
|regulation of protein export from nucleus|
|phosphotyrosine residue binding|
|negative regulation of lipid localization|
|phosphoprotein phosphatase activity|
|hindbrain morphogenesis|
|positive regulation of glucose transmembrane transport|
|cellular response to epidermal growth factor stimulus|
|regulation of endocrine process|
|body morphogenesis|
|negative regulation of peptide hormone secretion|
|regulation of cell adhesion mediated by integrin|
|response to epidermal growth factor|
|genitalia development|
|cerebellar cortex development|
|face development|
|regulation of interferon-beta production|
|epidermal growth factor receptor signaling pathway|
|SH3/SH2 adaptor activity|
|astrocyte differentiation|
|T cell costimulation|
|lymphocyte costimulation|
|regulation of glucose import|
|receptor tyrosine kinase binding|
|cell adhesion molecule binding|
|myeloid cell development|
|negative regulation of hormone secretion|
|regulation of insulin receptor signaling pathway|
|ERBB signaling pathway|
|regulation of cellular response to insulin stimulus|
|regulation of glucose transmembrane transport|
|triglyceride metabolic process|
|positive regulation of type I interferon production|
|cellular response to mechanical stimulus|
|fibroblast growth factor receptor signaling pathway|
|multicellular organism growth|
|epithelial cell migration|
|positive regulation of tumor necrosis factor production|
|epithelium migration|
|ephrin receptor signaling pathway|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|tissue migration|
|integrin-mediated signaling pathway|
|positive regulation of interleukin-6 production|
|organ growth|
|acylglycerol metabolic process|
|regulation of response to drug|
|neutral lipid metabolic process|
|protein tyrosine phosphatase activity|
|cerebellum development|
|peptidyl-tyrosine dephosphorylation|
|regulation of nucleocytoplasmic transport|
|regulation of lipid transport|
|cellular response to fibroblast growth factor stimulus|
|metencephalon development|
|response to fibroblast growth factor|
|regulation of type I interferon production|
|positive regulation of hormone secretion|
|negative regulation of protein secretion|
|DNA damage checkpoint|
|platelet activation|
|regulation of lipid localization|
|negative regulation of peptide secretion|
|regulation of interleukin-6 production|
|DNA integrity checkpoint|
|regulation of tumor necrosis factor production|
|positive regulation of mitotic cell cycle|
|hindbrain development|
|regulation of tumor necrosis factor superfamily cytokine production|
|activation of MAPK activity|
|regulation of cytokine-mediated signaling pathway|
|positive regulation of protein kinase B signaling|
|hormone-mediated signaling pathway|
|glial cell differentiation|
|ameboidal-type cell migration|
|regulation of response to cytokine stimulus|
|regulation of insulin secretion|
|negative regulation of protein transport|
|glucose homeostasis|
|carbohydrate homeostasis|
|negative regulation of establishment of protein localization|
|tissue homeostasis|
|positive regulation of peptidyl-tyrosine phosphorylation|
|cell cycle checkpoint|
|inner ear development|
|homeostasis of number of cells|
|bone development|
|positive regulation of transmembrane transport|
|hormone metabolic process|
|positive regulation of T cell activation|
|negative regulation of secretion by cell|
|regulation of peptide hormone secretion|
|positive regulation of ERK1 and ERK2 cascade|
|response to mechanical stimulus|
|protein dephosphorylation|
|gliogenesis|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of protein kinase B signaling|
|myeloid cell differentiation|
|ear development|
|regulation of intracellular protein transport|
|negative regulation of secretion|
|protein domain specific binding|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of cell-cell adhesion|
|axon guidance|
|positive regulation of MAP kinase activity|
|neuron projection guidance|
|sex differentiation|
|regulation of hormone secretion|
|negative regulation of cell adhesion|
|blood coagulation|
|regulation of ERK1 and ERK2 cascade|
|coagulation|
|regulation of leukocyte cell-cell adhesion|
|hemostasis|
|dephosphorylation|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|regulation of T cell activation|
|multicellular organismal homeostasis|
|activation of protein kinase activity|
|cellular response to external stimulus|
|positive regulation of protein serine/threonine kinase activity|
|anatomical structure homeostasis|
|regulation of MAP kinase activity|
|regulation of intracellular transport|
|positive regulation of lymphocyte activation|
|axonogenesis|
|positive regulation of cell cycle|
|leukocyte migration|
|glycerolipid metabolic process|
|developmental growth|
|growth|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|positive regulation of secretion by cell|
|axon development|
|positive regulation of cell activation|
|reproductive structure development|
|reproductive system development|
|cell morphogenesis involved in neuron differentiation|
|positive regulation of secretion|
|positive regulation of cytokine production|
|regulation of protein complex assembly|
|regulation of innate immune response|
|protein kinase binding|
|regulation of protein secretion|
|wound healing|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|negative regulation of transport|
|cell projection morphogenesis|
|regulation of peptide secretion|
|skeletal system development|
|regulation of body fluid levels|
|cellular response to growth factor stimulus|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of lymphocyte activation|
|cell part morphogenesis|
|regulation of protein serine/threonine kinase activity|
|regulation of response to biotic stimulus|
|heart development|
|response to growth factor|
|positive regulation of protein kinase activity|
|regulation of hormone levels|
|regulation of cellular protein localization|
|positive regulation of MAPK cascade|
|sensory organ development|
|chemotaxis|
|taxis|
|hemopoiesis|
|cell morphogenesis involved in differentiation|
|regulation of transmembrane transport|
|response to wounding|
|negative regulation of cell cycle|
|positive regulation of kinase activity|
|regulation of system process|
|protein-containing complex|
|regulation of leukocyte activation|
|cellular response to hormone stimulus|
|hematopoietic or lymphoid organ development|
|regulation of mitotic cell cycle|
|regulation of cell activation|
|immune system development|
|positive regulation of transferase activity|
|neuron projection development|
|developmental process involved in reproduction|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|mitotic cell cycle|
|regulation of cytokine production|
|regulation of protein transport|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|regulation of peptide transport|
|brain development|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of defense response|
|regulation of multi-organism process|
|cellular response to DNA damage stimulus|
|head development|
|regulation of protein kinase activity|
|regulation of secretion|
|neuron development|
|cellular component morphogenesis|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|circulatory system development|
|regulation of kinase activity|
|anatomical structure formation involved in morphogenesis|
|response to hormone|
|regulation of cellular localization|
|cellular lipid metabolic process|
|regulation of cellular component biogenesis|
|cell migration|
|regulation of transferase activity|
|central nervous system development|
|positive regulation of transport|
|cellular response to cytokine stimulus|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|positive regulation of phosphorylation|
|cell activation|
|cell motility|
|localization of cell|
|regulation of response to external stimulus|
|response to cytokine|
|chemical homeostasis|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|response to abiotic stimulus|
|cell projection organization|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|mitochondrion|
|locomotion|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|generation of neurons|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|neurogenesis|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|regulation of immune system process|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-2.34|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-1.91|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|-1.85|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-1.78|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-1.71|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.71|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|1.72|
|[[:results:exp392|PT-1 25μM R07 exp392]]|1.78|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|1.78|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|1.82|
|[[:results:exp136|MS094 2μM R03 exp136]]|1.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 93/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|6/28|
|blood|11/28|
|bone|4/26|
|breast|5/33|
|central nervous system|5/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|3/16|
|kidney|2/21|
|liver|3/20|
|lung|10/75|
|lymphocyte|2/16|
|ovary|4/26|
|pancreas|0/24|
|peripheral nervous system|2/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18056
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PTPN11 Expression in NALM6 Cells: 7.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>