PTPN11
Gene Information
- Official Symbol: PTPN11
- Official Name: protein tyrosine phosphatase non-receptor type 11
- Aliases and Previous Symbols: N/A
- Entrez ID: 5781
- UniProt: Q06124
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016].
- UniProt Summary: Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway (PubMed:28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73 (PubMed:26742426). {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:18559669, ECO:0000269|PubMed:18829466, ECO:0000269|PubMed:26742426, ECO:0000269|PubMed:28074573}.
Pfam Domains GO Terms
Pfam Domains
| Y phosphatase |
| SH2 |
GO Terms
| negative regulation of cortisol secretion |
| intestinal epithelial cell migration |
| negative regulation of steroid hormone secretion |
| negative regulation of growth hormone secretion |
| negative regulation of glucocorticoid secretion |
| abortive mitotic cell cycle |
| negative regulation of corticosteroid hormone secretion |
| regulation of cortisol secretion |
| atrioventricular canal development |
| Bergmann glial cell differentiation |
| non-membrane spanning protein tyrosine phosphatase activity |
| D1 dopamine receptor binding |
| regulation of glucocorticoid secretion |
| peptide hormone receptor binding |
| insulin receptor substrate binding |
| negative regulation of cell adhesion mediated by integrin |
| regulation of growth hormone secretion |
| regulation of corticosteroid hormone secretion |
| phospholipase binding |
| interleukin-6-mediated signaling pathway |
| megakaryocyte development |
| platelet formation |
| regulation of steroid hormone secretion |
| microvillus organization |
| platelet morphogenesis |
| neurotrophin TRK receptor signaling pathway |
| cerebellar cortex formation |
| megakaryocyte differentiation |
| positive regulation of insulin receptor signaling pathway |
| insulin receptor binding |
| positive regulation of cellular response to insulin stimulus |
| bone cell development |
| negative regulation of lipid transport |
| negative regulation of response to drug |
| neurotrophin signaling pathway |
| homeostasis of number of cells within a tissue |
| cerebellar cortex morphogenesis |
| positive regulation of interferon-beta production |
| face morphogenesis |
| cellular response to interleukin-6 |
| platelet-derived growth factor receptor signaling pathway |
| regulation of type I interferon-mediated signaling pathway |
| response to interleukin-6 |
| positive regulation of glucose import |
| head morphogenesis |
| cerebellum morphogenesis |
| negative regulation of insulin secretion |
| regulation of protein export from nucleus |
| phosphotyrosine residue binding |
| negative regulation of lipid localization |
| phosphoprotein phosphatase activity |
| hindbrain morphogenesis |
| positive regulation of glucose transmembrane transport |
| cellular response to epidermal growth factor stimulus |
| regulation of endocrine process |
| body morphogenesis |
| negative regulation of peptide hormone secretion |
| regulation of cell adhesion mediated by integrin |
| response to epidermal growth factor |
| genitalia development |
| cerebellar cortex development |
| face development |
| regulation of interferon-beta production |
| epidermal growth factor receptor signaling pathway |
| SH3/SH2 adaptor activity |
| astrocyte differentiation |
| T cell costimulation |
| lymphocyte costimulation |
| regulation of glucose import |
| receptor tyrosine kinase binding |
| cell adhesion molecule binding |
| myeloid cell development |
| negative regulation of hormone secretion |
| regulation of insulin receptor signaling pathway |
| ERBB signaling pathway |
| regulation of cellular response to insulin stimulus |
| regulation of glucose transmembrane transport |
| triglyceride metabolic process |
| positive regulation of type I interferon production |
| cellular response to mechanical stimulus |
| fibroblast growth factor receptor signaling pathway |
| multicellular organism growth |
| epithelial cell migration |
| positive regulation of tumor necrosis factor production |
| epithelium migration |
| ephrin receptor signaling pathway |
| positive regulation of tumor necrosis factor superfamily cytokine production |
| tissue migration |
| integrin-mediated signaling pathway |
| positive regulation of interleukin-6 production |
| organ growth |
| acylglycerol metabolic process |
| regulation of response to drug |
| neutral lipid metabolic process |
| protein tyrosine phosphatase activity |
| cerebellum development |
| peptidyl-tyrosine dephosphorylation |
| regulation of nucleocytoplasmic transport |
| regulation of lipid transport |
| cellular response to fibroblast growth factor stimulus |
| metencephalon development |
| response to fibroblast growth factor |
| regulation of type I interferon production |
| positive regulation of hormone secretion |
| negative regulation of protein secretion |
| DNA damage checkpoint |
| platelet activation |
| regulation of lipid localization |
| negative regulation of peptide secretion |
| regulation of interleukin-6 production |
| DNA integrity checkpoint |
| regulation of tumor necrosis factor production |
| positive regulation of mitotic cell cycle |
| hindbrain development |
| regulation of tumor necrosis factor superfamily cytokine production |
| activation of MAPK activity |
| regulation of cytokine-mediated signaling pathway |
| positive regulation of protein kinase B signaling |
| hormone-mediated signaling pathway |
| glial cell differentiation |
| ameboidal-type cell migration |
| regulation of response to cytokine stimulus |
| regulation of insulin secretion |
| negative regulation of protein transport |
| glucose homeostasis |
| carbohydrate homeostasis |
| negative regulation of establishment of protein localization |
| tissue homeostasis |
| positive regulation of peptidyl-tyrosine phosphorylation |
| cell cycle checkpoint |
| inner ear development |
| homeostasis of number of cells |
| bone development |
| positive regulation of transmembrane transport |
| hormone metabolic process |
| positive regulation of T cell activation |
| negative regulation of secretion by cell |
| regulation of peptide hormone secretion |
| positive regulation of ERK1 and ERK2 cascade |
| response to mechanical stimulus |
| protein dephosphorylation |
| gliogenesis |
| positive regulation of leukocyte cell-cell adhesion |
| regulation of protein kinase B signaling |
| myeloid cell differentiation |
| ear development |
| regulation of intracellular protein transport |
| negative regulation of secretion |
| protein domain specific binding |
| regulation of peptidyl-tyrosine phosphorylation |
| positive regulation of cell-cell adhesion |
| axon guidance |
| positive regulation of MAP kinase activity |
| neuron projection guidance |
| sex differentiation |
| regulation of hormone secretion |
| negative regulation of cell adhesion |
| blood coagulation |
| regulation of ERK1 and ERK2 cascade |
| coagulation |
| regulation of leukocyte cell-cell adhesion |
| hemostasis |
| dephosphorylation |
| cellular response to abiotic stimulus |
| cellular response to environmental stimulus |
| regulation of T cell activation |
| multicellular organismal homeostasis |
| activation of protein kinase activity |
| cellular response to external stimulus |
| positive regulation of protein serine/threonine kinase activity |
| anatomical structure homeostasis |
| regulation of MAP kinase activity |
| regulation of intracellular transport |
| positive regulation of lymphocyte activation |
| axonogenesis |
| positive regulation of cell cycle |
| leukocyte migration |
| glycerolipid metabolic process |
| developmental growth |
| growth |
| regulation of cell-cell adhesion |
| positive regulation of leukocyte activation |
| positive regulation of cell adhesion |
| positive regulation of secretion by cell |
| axon development |
| positive regulation of cell activation |
| reproductive structure development |
| reproductive system development |
| cell morphogenesis involved in neuron differentiation |
| positive regulation of secretion |
| positive regulation of cytokine production |
| regulation of protein complex assembly |
| regulation of innate immune response |
| protein kinase binding |
| regulation of protein secretion |
| wound healing |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| negative regulation of transport |
| cell projection morphogenesis |
| regulation of peptide secretion |
| skeletal system development |
| regulation of body fluid levels |
| cellular response to growth factor stimulus |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| regulation of lymphocyte activation |
| cell part morphogenesis |
| regulation of protein serine/threonine kinase activity |
| regulation of response to biotic stimulus |
| heart development |
| response to growth factor |
| positive regulation of protein kinase activity |
| regulation of hormone levels |
| regulation of cellular protein localization |
| positive regulation of MAPK cascade |
| sensory organ development |
| chemotaxis |
| taxis |
| hemopoiesis |
| cell morphogenesis involved in differentiation |
| regulation of transmembrane transport |
| response to wounding |
| negative regulation of cell cycle |
| positive regulation of kinase activity |
| regulation of system process |
| protein-containing complex |
| regulation of leukocyte activation |
| cellular response to hormone stimulus |
| hematopoietic or lymphoid organ development |
| regulation of mitotic cell cycle |
| regulation of cell activation |
| immune system development |
| positive regulation of transferase activity |
| neuron projection development |
| developmental process involved in reproduction |
| cytokine-mediated signaling pathway |
| regulation of cell adhesion |
| mitotic cell cycle |
| regulation of cytokine production |
| regulation of protein transport |
| enzyme linked receptor protein signaling pathway |
| cell morphogenesis |
| regulation of peptide transport |
| brain development |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of MAPK cascade |
| regulation of defense response |
| regulation of multi-organism process |
| cellular response to DNA damage stimulus |
| head development |
| regulation of protein kinase activity |
| regulation of secretion |
| neuron development |
| cellular component morphogenesis |
| multicellular organismal reproductive process |
| multicellular organism reproduction |
| circulatory system development |
| regulation of kinase activity |
| anatomical structure formation involved in morphogenesis |
| response to hormone |
| regulation of cellular localization |
| cellular lipid metabolic process |
| regulation of cellular component biogenesis |
| cell migration |
| regulation of transferase activity |
| central nervous system development |
| positive regulation of transport |
| cellular response to cytokine stimulus |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| regulation of protein localization |
| positive regulation of phosphorylation |
| cell activation |
| cell motility |
| localization of cell |
| regulation of response to external stimulus |
| response to cytokine |
| chemical homeostasis |
| plasma membrane bounded cell projection organization |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| regulation of immune response |
| positive regulation of immune system process |
| response to abiotic stimulus |
| cell projection organization |
| regulation of cell cycle |
| negative regulation of multicellular organismal process |
| lipid metabolic process |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| mitochondrion |
| locomotion |
| cell cycle |
| negative regulation of cell communication |
| negative regulation of signaling |
| reproductive process |
| reproduction |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| regulation of response to stress |
| generation of neurons |
| movement of cell or subcellular component |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| negative regulation of response to stimulus |
| neurogenesis |
| homeostatic process |
| cell development |
| positive regulation of signal transduction |
| regulation of immune system process |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 93/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 6/28 |
| blood | 11/28 |
| bone | 4/26 |
| breast | 5/33 |
| central nervous system | 5/56 |
| cervix | 0/4 |
| colorectal | 1/17 |
| esophagus | 2/13 |
| fibroblast | 0/1 |
| gastric | 3/16 |
| kidney | 2/21 |
| liver | 3/20 |
| lung | 10/75 |
| lymphocyte | 2/16 |
| ovary | 4/26 |
| pancreas | 0/24 |
| peripheral nervous system | 2/16 |
| plasma cell | 2/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 3/22 |
| urinary tract | 2/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18056
- Expression level (log2 read counts): 7.95
Expression Distribution
PTPN11 Expression in NALM6 Cells: 7.95
