PTPN1 [The Human Chemical-Genetic Interaction Map Project]

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======= PTPN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PTPN1
  * **<color #00a2e8>Official Name</color>**: protein tyrosine phosphatase non-receptor type 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5770|5770]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P18031|P18031]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PTPN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PTPN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/176885|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. {ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:21135139, ECO:0000269|PubMed:22169477}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Y phosphatase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cytoplasmic side of endoplasmic reticulum membrane|
|regulation of hepatocyte growth factor receptor signaling pathway|
|peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity|
|positive regulation of receptor catabolic process|
|negative regulation of PERK-mediated unfolded protein response|
|sorting endosome|
|platelet-derived growth factor receptor-beta signaling pathway|
|positive regulation of IRE1-mediated unfolded protein response|
|regulation of receptor catabolic process|
|regulation of PERK-mediated unfolded protein response|
|negative regulation of endoplasmic reticulum unfolded protein response|
|regulation of IRE1-mediated unfolded protein response|
|positive regulation of endoplasmic reticulum unfolded protein response|
|negative regulation of vascular endothelial growth factor receptor signaling pathway|
|growth hormone receptor signaling pathway via JAK-STAT|
|growth hormone receptor signaling pathway|
|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|
|cellular response to growth hormone stimulus|
|insulin receptor binding|
|regulation of endoplasmic reticulum unfolded protein response|
|ephrin receptor binding|
|protein phosphatase 2A binding|
|regulation of vascular endothelial growth factor receptor signaling pathway|
|regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|
|platelet-derived growth factor receptor signaling pathway|
|response to growth hormone|
|negative regulation of insulin receptor signaling pathway|
|regulation of type I interferon-mediated signaling pathway|
|negative regulation of cellular response to insulin stimulus|
|positive regulation of response to endoplasmic reticulum stress|
|activation of JUN kinase activity|
|negative regulation of response to endoplasmic reticulum stress|
|IRE1-mediated unfolded protein response|
|positive regulation of protein tyrosine kinase activity|
|receptor tyrosine kinase binding|
|regulation of insulin receptor signaling pathway|
|actin cytoskeleton reorganization|
|negative regulation of ERK1 and ERK2 cascade|
|positive regulation of JUN kinase activity|
|regulation of cellular response to insulin stimulus|
|negative regulation of MAP kinase activity|
|JNK cascade|
|regulation of response to endoplasmic reticulum stress|
|regulation of JUN kinase activity|
|insulin receptor signaling pathway|
|regulation of protein tyrosine kinase activity|
|negative regulation of intrinsic apoptotic signaling pathway|
|protein tyrosine phosphatase activity|
|peptidyl-tyrosine dephosphorylation|
|stress-activated MAPK cascade|
|endoplasmic reticulum unfolded protein response|
|cellular response to unfolded protein|
|negative regulation of protein serine/threonine kinase activity|
|positive regulation of JNK cascade|
|stress-activated protein kinase signaling cascade|
|negative regulation of cellular response to growth factor stimulus|
|cellular response to topologically incorrect protein|
|activation of MAPK activity|
|regulation of intrinsic apoptotic signaling pathway|
|cellular response to insulin stimulus|
|response to unfolded protein|
|regulation of cytokine-mediated signaling pathway|
|positive regulation of stress-activated MAPK cascade|
|negative regulation of MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|regulation of response to cytokine stimulus|
|regulation of JNK cascade|
|response to topologically incorrect protein|
|positive regulation of peptidyl-tyrosine phosphorylation|
|regulation of endocytosis|
|protein dephosphorylation|
|negative regulation of apoptotic signaling pathway|
|negative regulation of protein kinase activity|
|response to insulin|
|regulation of intracellular protein transport|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|negative regulation of kinase activity|
|regulation of peptidyl-tyrosine phosphorylation|
|early endosome|
|response to endoplasmic reticulum stress|
|positive regulation of MAP kinase activity|
|cellular response to peptide hormone stimulus|
|regulation of cellular response to growth factor stimulus|
|negative regulation of transferase activity|
|regulation of ERK1 and ERK2 cascade|
|dephosphorylation|
|cadherin binding|
|cellular response to peptide|
|activation of protein kinase activity|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|enzyme binding|
|regulation of intracellular transport|
|positive regulation of cellular catabolic process|
|MAPK cascade|
|response to peptide hormone|
|signal transduction by protein phosphorylation|
|regulation of apoptotic signaling pathway|
|negative regulation of protein phosphorylation|
|positive regulation of catabolic process|
|negative regulation of phosphorylation|
|regulation of innate immune response|
|protein kinase binding|
|response to peptide|
|actin cytoskeleton organization|
|negative regulation of intracellular signal transduction|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of protein serine/threonine kinase activity|
|regulation of response to biotic stimulus|
|positive regulation of protein kinase activity|
|regulation of cellular protein localization|
|positive regulation of MAPK cascade|
|regulation of vesicle-mediated transport|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|actin filament-based process|
|positive regulation of kinase activity|
|negative regulation of protein modification process|
|protein-containing complex|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|regulation of protein transport|
|enzyme linked receptor protein signaling pathway|
|regulation of cellular response to stress|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of MAPK cascade|
|regulation of defense response|
|regulation of multi-organism process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of cellular catabolic process|
|zinc ion binding|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|regulation of cellular localization|
|protein phosphorylation|
|regulation of transferase activity|
|negative regulation of cell death|
|regulation of catabolic process|
|response to organonitrogen compound|
|endoplasmic reticulum|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|response to nitrogen compound|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|regulation of immune response|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|phosphorylation|
|negative regulation of cell communication|
|negative regulation of signaling|
|RNA binding|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-1.72|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|1.87|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|1.92|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|1.99|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.12|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|3/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3928
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PTPN1 Expression in NALM6 Cells: 6.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>