PTPN1

Gene Information

Official Symbol: PTPN1
Official Name: protein tyrosine phosphatase non-receptor type 1
Aliases and Previous Symbols: N/A
Entrez ID: 5770
UniProt: P18031
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013].
UniProt Summary: Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. {ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:21135139, ECO:0000269|PubMed:22169477}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
NN-Dimethylsphingosine 2.5μM R08 exp508	-1.72
MK-1775 0.32μM R02 exp75	1.87
Fluvastatin 2.2μM R06 exp282	1.92
Cerivastatin 0.15μM R05 exp226	1.99
LY2090314 0.003μM R08 exp499	2.12

Global Fraction of Cell Lines Where Essential: 4/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	3/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3928
Expression level (log2 read counts): 6.21

Expression Distribution

cytoplasmic side of endoplasmic reticulum membrane
regulation of hepatocyte growth factor receptor signaling pathway
peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
positive regulation of receptor catabolic process
negative regulation of PERK-mediated unfolded protein response
sorting endosome
platelet-derived growth factor receptor-beta signaling pathway
positive regulation of IRE1-mediated unfolded protein response
regulation of receptor catabolic process
regulation of PERK-mediated unfolded protein response
negative regulation of endoplasmic reticulum unfolded protein response
regulation of IRE1-mediated unfolded protein response
positive regulation of endoplasmic reticulum unfolded protein response
negative regulation of vascular endothelial growth factor receptor signaling pathway
growth hormone receptor signaling pathway via JAK-STAT
growth hormone receptor signaling pathway
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
cellular response to growth hormone stimulus
insulin receptor binding
regulation of endoplasmic reticulum unfolded protein response
ephrin receptor binding
protein phosphatase 2A binding
regulation of vascular endothelial growth factor receptor signaling pathway
regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
platelet-derived growth factor receptor signaling pathway
response to growth hormone
negative regulation of insulin receptor signaling pathway
regulation of type I interferon-mediated signaling pathway
negative regulation of cellular response to insulin stimulus
positive regulation of response to endoplasmic reticulum stress
activation of JUN kinase activity
negative regulation of response to endoplasmic reticulum stress
IRE1-mediated unfolded protein response
positive regulation of protein tyrosine kinase activity
receptor tyrosine kinase binding
regulation of insulin receptor signaling pathway
actin cytoskeleton reorganization
negative regulation of ERK1 and ERK2 cascade
positive regulation of JUN kinase activity
regulation of cellular response to insulin stimulus