PTPRG

Gene Information

Official Symbol: PTPRG
Official Name: protein tyrosine phosphatase receptor type G
Aliases and Previous Symbols: N/A
Entrez ID: 5793
UniProt: P23470
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Possesses tyrosine phosphatase activity. {ECO:0000269|PubMed:19167335}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5971
Expression level (log2 read counts): -0.33

Expression Distribution

Screen	Score
Staurosporine 0.02μM R08 exp524	-1.85
Clomiphene 4.4μM R02 exp68	1.77
5-Fluorouracil 20μM R00 exp2	1.81

fn3
Y phosphatase
Carb anhydrase

regulation of homophilic cell adhesion
transmembrane receptor protein tyrosine phosphatase activity
negative regulation of epithelial cell migration
protein tyrosine phosphatase activity
peptidyl-tyrosine dephosphorylation
negative regulation of neuron projection development
negative regulation of cell projection organization
protein dephosphorylation
regulation of epithelial cell migration
negative regulation of neuron differentiation
negative regulation of cell migration
negative regulation of cell motility
negative regulation of neurogenesis
dephosphorylation
negative regulation of cellular component movement
negative regulation of nervous system development
negative regulation of locomotion
negative regulation of cell development
regulation of cell-cell adhesion
regulation of neuron projection development
transmembrane receptor protein tyrosine kinase signaling pathway
regulation of neuron differentiation
regulation of cell adhesion
regulation of plasma membrane bounded cell projection organization
negative regulation of cellular component organization
regulation of cell projection organization
negative regulation of cell differentiation
enzyme linked receptor protein signaling pathway
brain development
head development
regulation of neurogenesis
regulation of cell migration
regulation of cell motility
regulation of nervous system development
regulation of cell development
negative regulation of developmental process
central nervous system development
regulation of locomotion
regulation of cellular component movement
identical protein binding