PTPRK

Entrez Summary: N/A
UniProt Summary: Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa. {ECO:0000269|PubMed:19836242}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

leading edge membrane
gamma-catenin binding
negative regulation of keratinocyte proliferation
transmembrane receptor protein tyrosine phosphatase activity
protein localization to cell surface
focal adhesion assembly
cell-substrate adherens junction assembly
regulation of keratinocyte proliferation
adherens junction assembly
cell-substrate junction assembly
photoreceptor outer segment
adherens junction
beta-catenin binding
cellular response to UV
adherens junction organization
protein tyrosine phosphatase activity
transforming growth factor beta receptor signaling pathway
peptidyl-tyrosine dephosphorylation
cellular response to light stimulus
negative regulation of epithelial cell proliferation
cell-matrix adhesion
cellular response to reactive oxygen species
response to UV
cellular response to transforming growth factor beta stimulus
response to transforming growth factor beta
cell junction assembly
cell-cell junction
cellular response to radiation
cell-substrate adhesion
response to reactive oxygen species
transmembrane receptor protein serine/threonine kinase signaling pathway
cell junction organization
protein dephosphorylation
cellular response to oxidative stress
negative regulation of cell migration
negative regulation of cell motility
axon
response to light stimulus
dephosphorylation
negative regulation of cellular component movement