PTPRM [The Human Chemical-Genetic Interaction Map Project]

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======= PTPRM =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PTPRM
  * **<color #00a2e8>Official Name</color>**: protein tyrosine phosphatase receptor type M
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5797|5797]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P28827|P28827]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PTPRM&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PTPRM|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/176888|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control. {ECO:0000269|PubMed:16456543}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|fn3|
|Y phosphatase|
|MAM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|transmembrane receptor protein tyrosine phosphatase activity|
|retinal ganglion cell axon guidance|
|retina layer formation|
|negative regulation of endothelial cell proliferation|
|retina morphogenesis in camera-type eye|
|negative regulation of endothelial cell migration|
|neural retina development|
|positive regulation of blood vessel diameter|
|negative regulation of epithelial cell migration|
|protein tyrosine phosphatase activity|
|negative regulation of angiogenesis|
|peptidyl-tyrosine dephosphorylation|
|cell-cell adherens junction|
|negative regulation of blood vessel morphogenesis|
|camera-type eye morphogenesis|
|negative regulation of vasculature development|
|negative regulation of epithelial cell proliferation|
|regulation of endothelial cell proliferation|
|regulation of tube diameter|
|regulation of blood vessel diameter|
|regulation of tube size|
|retina development in camera-type eye|
|eye morphogenesis|
|regulation of endothelial cell migration|
|homophilic cell adhesion via plasma membrane adhesion molecules|
|vascular process in circulatory system|
|cell-cell junction|
|lamellipodium|
|protein dephosphorylation|
|regulation of epithelial cell migration|
|sensory organ morphogenesis|
|negative regulation of cell migration|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|axon guidance|
|neuron projection guidance|
|negative regulation of cell motility|
|regulation of angiogenesis|
|dephosphorylation|
|negative regulation of cellular component movement|
|cadherin binding|
|camera-type eye development|
|regulation of vasculature development|
|negative regulation of locomotion|
|regulation of epithelial cell proliferation|
|eye development|
|visual system development|
|sensory system development|
|axonogenesis|
|blood circulation|
|circulatory system process|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell-cell adhesion|
|regulation of anatomical structure size|
|cell part morphogenesis|
|sensory organ development|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|neuron projection development|
|negative regulation of cell population proliferation|
|perinuclear region of cytoplasm|
|cell morphogenesis|
|neuron development|
|cellular component morphogenesis|
|regulation of cell migration|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|cell adhesion|
|biological adhesion|
|negative regulation of developmental process|
|animal organ morphogenesis|
|regulation of locomotion|
|regulation of cellular component movement|
|neuron differentiation|
|response to drug|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|negative regulation of multicellular organismal process|
|locomotion|
|integral component of plasma membrane|
|generation of neurons|
|movement of cell or subcellular component|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-1.96|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-1.9|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|-1.84|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-1.82|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-1.81|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-1.74|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|-1.73|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15514
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PTPRM Expression in NALM6 Cells: 4.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>