PTPRM
Gene Information
- Official Symbol: PTPRM
- Official Name: protein tyrosine phosphatase receptor type M
- Aliases and Previous Symbols: N/A
- Entrez ID: 5797
- UniProt: P28827
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control. {ECO:0000269|PubMed:16456543}.
Pfam Domains GO Terms
Pfam Domains
| fn3 |
| Y phosphatase |
| MAM |
GO Terms
| transmembrane receptor protein tyrosine phosphatase activity |
| retinal ganglion cell axon guidance |
| retina layer formation |
| negative regulation of endothelial cell proliferation |
| retina morphogenesis in camera-type eye |
| negative regulation of endothelial cell migration |
| neural retina development |
| positive regulation of blood vessel diameter |
| negative regulation of epithelial cell migration |
| protein tyrosine phosphatase activity |
| negative regulation of angiogenesis |
| peptidyl-tyrosine dephosphorylation |
| cell-cell adherens junction |
| negative regulation of blood vessel morphogenesis |
| camera-type eye morphogenesis |
| negative regulation of vasculature development |
| negative regulation of epithelial cell proliferation |
| regulation of endothelial cell proliferation |
| regulation of tube diameter |
| regulation of blood vessel diameter |
| regulation of tube size |
| retina development in camera-type eye |
| eye morphogenesis |
| regulation of endothelial cell migration |
| homophilic cell adhesion via plasma membrane adhesion molecules |
| vascular process in circulatory system |
| cell-cell junction |
| lamellipodium |
| protein dephosphorylation |
| regulation of epithelial cell migration |
| sensory organ morphogenesis |
| negative regulation of cell migration |
| cell-cell adhesion via plasma-membrane adhesion molecules |
| axon guidance |
| neuron projection guidance |
| negative regulation of cell motility |
| regulation of angiogenesis |
| dephosphorylation |
| negative regulation of cellular component movement |
| cadherin binding |
| camera-type eye development |
| regulation of vasculature development |
| negative regulation of locomotion |
| regulation of epithelial cell proliferation |
| eye development |
| visual system development |
| sensory system development |
| axonogenesis |
| blood circulation |
| circulatory system process |
| axon development |
| cell morphogenesis involved in neuron differentiation |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| cell-cell adhesion |
| regulation of anatomical structure size |
| cell part morphogenesis |
| sensory organ development |
| chemotaxis |
| taxis |
| cell morphogenesis involved in differentiation |
| neuron projection development |
| negative regulation of cell population proliferation |
| perinuclear region of cytoplasm |
| cell morphogenesis |
| neuron development |
| cellular component morphogenesis |
| regulation of cell migration |
| anatomical structure formation involved in morphogenesis |
| regulation of cell motility |
| cell adhesion |
| biological adhesion |
| negative regulation of developmental process |
| animal organ morphogenesis |
| regulation of locomotion |
| regulation of cellular component movement |
| neuron differentiation |
| response to drug |
| regulation of anatomical structure morphogenesis |
| identical protein binding |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| negative regulation of multicellular organismal process |
| locomotion |
| integral component of plasma membrane |
| generation of neurons |
| movement of cell or subcellular component |
| regulation of cell population proliferation |
| neurogenesis |
| cell development |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Wortmannin 5μM R00 exp38 | -1.96 |
| UM131593 0.1μM R01 exp58 | -1.9 |
| BI-6727 0.001μM R01 exp42 | -1.84 |
| Docosahexaenoic-acid 50μM R07 exp356 | -1.82 |
| BI-2536 0.02μM R03 exp96 | -1.81 |
| 5-Fluorouracil 2μM R00 exp1 | -1.74 |
| Resminostat 0.5μM R07 exp393 | -1.73 |
| Chloramphenicol 2μM R00 exp12 | -1.71 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15514
- Expression level (log2 read counts): 4.93
Expression Distribution
PTPRM Expression in NALM6 Cells: 4.93
