PTPRR

Entrez Summary: N/A
UniProt Summary: Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of homophilic cell adhesion
transmembrane receptor protein tyrosine phosphatase activity
ERBB2 signaling pathway
negative regulation of epithelial cell migration
negative regulation of ERK1 and ERK2 cascade
ERBB signaling pathway
protein tyrosine phosphatase activity
peptidyl-tyrosine dephosphorylation
negative regulation of MAPK cascade
protein dephosphorylation
regulation of epithelial cell migration
negative regulation of cell migration
negative regulation of cell motility
regulation of ERK1 and ERK2 cascade
negative regulation of cellular component movement
dephosphorylation
negative regulation of locomotion
in utero embryonic development
regulation of cell-cell adhesion
negative regulation of protein phosphorylation
negative regulation of phosphorylation
protein kinase binding
negative regulation of intracellular signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
cell junction
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
chordate embryonic development
embryo development ending in birth or egg hatching
regulation of cell adhesion
perinuclear region of cytoplasm
enzyme linked receptor protein signaling pathway
regulation of MAPK cascade
regulation of cell migration
regulation of cell motility
embryo development
regulation of locomotion
regulation of cellular component movement
negative regulation of cellular protein metabolic process