PTPRT [The Human Chemical-Genetic Interaction Map Project]

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======= PTPRT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PTPRT
  * **<color #00a2e8>Official Name</color>**: protein tyrosine phosphatase receptor type T
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11122|11122]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14522|O14522]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PTPRT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PTPRT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608712|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MAM|
|Y phosphatase|
|fn3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity|
|delta-catenin binding|
|STAT family protein binding|
|alpha-catenin binding|
|gamma-catenin binding|
|transmembrane receptor protein tyrosine phosphatase activity|
|negative regulation of receptor signaling pathway via STAT|
|cellular response to interleukin-6|
|response to interleukin-6|
|beta-catenin binding|
|protein phosphatase binding|
|protein tyrosine phosphatase activity|
|peptidyl-tyrosine dephosphorylation|
|regulation of receptor signaling pathway via STAT|
|homophilic cell adhesion via plasma membrane adhesion molecules|
|protein dephosphorylation|
|negative regulation of protein kinase activity|
|negative regulation of kinase activity|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|negative regulation of cell migration|
|negative regulation of cell motility|
|negative regulation of transferase activity|
|negative regulation of cellular component movement|
|dephosphorylation|
|cadherin binding|
|negative regulation of locomotion|
|negative regulation of protein phosphorylation|
|negative regulation of phosphorylation|
|cell-cell adhesion|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|cell surface|
|enzyme linked receptor protein signaling pathway|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of cell migration|
|regulation of kinase activity|
|protein homodimerization activity|
|regulation of cell motility|
|cell adhesion|
|biological adhesion|
|regulation of transferase activity|
|regulation of locomotion|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|negative regulation of cellular protein metabolic process|
|response to cytokine|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|integral component of plasma membrane|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4757
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PTPRT Expression in NALM6 Cells: -2.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>