PTPRT

Gene Information

Official Symbol: PTPRT
Official Name: protein tyrosine phosphatase receptor type T
Aliases and Previous Symbols: N/A
Entrez ID: 11122
UniProt: O14522
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4757
Expression level (log2 read counts): -2.43

Expression Distribution

MAM
Y phosphatase
fn3

peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
delta-catenin binding
STAT family protein binding
alpha-catenin binding
gamma-catenin binding
transmembrane receptor protein tyrosine phosphatase activity
negative regulation of receptor signaling pathway via STAT
cellular response to interleukin-6
response to interleukin-6
beta-catenin binding
protein phosphatase binding
protein tyrosine phosphatase activity
peptidyl-tyrosine dephosphorylation
regulation of receptor signaling pathway via STAT
homophilic cell adhesion via plasma membrane adhesion molecules
protein dephosphorylation
negative regulation of protein kinase activity
negative regulation of kinase activity
cell-cell adhesion via plasma-membrane adhesion molecules
negative regulation of cell migration
negative regulation of cell motility
negative regulation of transferase activity
negative regulation of cellular component movement
dephosphorylation
cadherin binding
negative regulation of locomotion
negative regulation of protein phosphorylation
negative regulation of phosphorylation
cell-cell adhesion
transmembrane receptor protein tyrosine kinase signaling pathway
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
cell surface
enzyme linked receptor protein signaling pathway
negative regulation of catalytic activity
regulation of protein kinase activity
regulation of cell migration
regulation of kinase activity
protein homodimerization activity