PTTG1IP

Gene Information

Official Symbol: PTTG1IP
Official Name: PTTG1 interacting protein
Aliases and Previous Symbols: N/A
Entrez ID: 754
UniProt: P53801
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a single-pass type I integral membrane protein, which binds to pituitary tumor-transforming 1 protein (PTTG1), and facilitates translocation of PTTG1 into the nucleus. Coexpression of this protein and PTTG1 induces transcriptional activation of basic fibroblast growth factor. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013].
UniProt Summary: May facilitate PTTG1 nuclear translocation.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5703
Expression level (log2 read counts): 5.71

Expression Distribution

Screen	Score
QNZ 0.01μM R05 exp241	-2.05
FK-506 5μM R07 exp358	1.86
Aminopterin 0.005μM R07 exp335	1.92

negative regulation of DNA damage response, signal transduction by p53 class mediator
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
regulation of intrinsic apoptotic signaling pathway by p53 class mediator
negative regulation of signal transduction by p53 class mediator
regulation of DNA damage response, signal transduction by p53 class mediator
p53 binding
negative regulation of response to DNA damage stimulus
protein import into nucleus
negative regulation of intrinsic apoptotic signaling pathway
import into nucleus
positive regulation of protein ubiquitination
positive regulation of protein modification by small protein conjugation or removal
positive regulation of cellular protein catabolic process
protein import
regulation of intrinsic apoptotic signaling pathway
protein localization to nucleus
regulation of signal transduction by p53 class mediator
regulation of protein ubiquitination
positive regulation of protein catabolic process
regulation of response to DNA damage stimulus
negative regulation of apoptotic signaling pathway
regulation of protein modification by small protein conjugation or removal
regulation of cellular protein catabolic process
nucleocytoplasmic transport
nuclear transport
positive regulation of cellular catabolic process
regulation of protein catabolic process
regulation of apoptotic signaling pathway
establishment of protein localization to organelle
positive regulation of catabolic process
negative regulation of intracellular signal transduction
regulation of cellular response to stress
protein localization to organelle
molecular function
regulation of cellular catabolic process
negative regulation of apoptotic process
negative regulation of programmed cell death
negative regulation of cell death
regulation of catabolic process
intracellular protein transport