PTX3

Gene Information

Official Symbol: PTX3
Official Name: pentraxin 3
Aliases and Previous Symbols: N/A
Entrez ID: 5806
UniProt: P26022
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the pentraxin protein family. The expression of this protein is induced by inflammatory cytokines in response to inflammatory stimuli in several mesenchymal and epithelial cell types, particularly endothelial cells and mononuclear phagocytes. The protein promotes fibrocyte differentiation and is involved in regulating inflammation and complement activation. It also plays a role in angiogenesis and tissue remodeling. The protein serves as a biomarker for several inflammatory conditions. [provided by RefSeq, Jun 2016].
UniProt Summary: Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self- components and female fertility. {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12388
Expression level (log2 read counts): -6.6

Expression Distribution

Screen	Score
MS023 7μM R03 exp135	-1.82
Isoniazid 100μM R08 exp494	-1.72
WYE-354 6μM R02 exp90	2.13

modulation by host of viral exo-alpha-sialidase activity
negative regulation by host of viral exo-alpha-sialidase activity
modulation by host of viral glycoprotein metabolic process
(1→3)-beta-D-glucan binding
negative regulation by host of symbiont catalytic activity
modulation by host of viral catalytic activity
negative regulation by host of viral glycoprotein metabolic process
negative regulation of exo-alpha-sialidase activity
modulation by host of viral molecular function
ovarian cumulus expansion
regulation of exo-alpha-sialidase activity
negative regulation of catalytic activity in other organism involved in symbiotic interaction
fused antrum stage
modulation by host of symbiont catalytic activity
modulation of catalytic activity in other organism involved in symbiotic interaction
response to yeast
mammalian oogenesis stage
negative regulation by host of symbiont molecular function
antral ovarian follicle growth
modulation by host of symbiont molecular function
complement component C1q binding
negative regulation of molecular function in other organism
negative regulation of molecular function in other organism involved in symbiotic interaction
opsonization
modulation of molecular function in other organism
modulation of molecular function in other organism involved in symbiotic interaction
negative regulation by host of viral process
virion binding
negative regulation of glycoprotein metabolic process
negative regulation of viral entry into host cell
modulation by host of viral process
regulation of viral entry into host cell
positive regulation of nitric oxide biosynthetic process
positive regulation of nitric oxide metabolic process
ovulation cycle process
regulation of glycoprotein metabolic process
response to fungus
positive regulation of reactive oxygen species biosynthetic process
ovarian follicle development
tertiary granule lumen