PUM2 [The Human Chemical-Genetic Interaction Map Project]

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======= PUM2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PUM2
  * **<color #00a2e8>Official Name</color>**: pumilio RNA binding family member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23369|23369]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TB72|Q8TB72]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PUM2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PUM2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607205|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (, PubMed:21397187). Mediates post- transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation- independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:22345517). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non- coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). May regulate DCUN1D3 mRNA levels (PubMed:25349211). May support proliferation and self-renewal of stem cells. Binds specifically to miRNA MIR199A precursor, with PUM1, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233). {ECO:0000269|PubMed:18776931, ECO:0000269|PubMed:21397187, ECO:0000269|PubMed:22345517, ECO:0000269|PubMed:22955276, ECO:0000269|PubMed:25340845, ECO:0000269|PubMed:25349211, ECO:0000269|PubMed:26724866, ECO:0000269|PubMed:28431233}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PUF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of RIG-I signaling pathway|
|stress granule assembly|
|regulation of RIG-I signaling pathway|
|regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway|
|positive regulation of gene silencing by miRNA|
|positive regulation of posttranscriptional gene silencing|
|production of miRNAs involved in gene silencing by miRNA|
|miRNA binding|
|dsRNA processing|
|production of small RNA involved in gene silencing by RNA|
|gene silencing by miRNA|
|posttranscriptional gene silencing by RNA|
|posttranscriptional gene silencing|
|cytoplasmic stress granule|
|regulation of defense response to virus|
|mRNA 3-UTR binding|
|regulation of gene silencing by miRNA|
|gene silencing by RNA|
|regulation of gene silencing by RNA|
|regulation of posttranscriptional gene silencing|
|regulation of chromosome segregation|
|regulation of gene silencing|
|gene silencing|
|regulation of mRNA stability|
|regulation of RNA stability|
|regulation of mRNA catabolic process|
|positive regulation of immune effector process|
|ribonucleoprotein complex assembly|
|regulation of gene expression, epigenetic|
|nuclear membrane|
|ribonucleoprotein complex subunit organization|
|regulation of mRNA metabolic process|
|positive regulation of innate immune response|
|regulation of translation|
|positive regulation of response to biotic stimulus|
|regulation of cellular amide metabolic process|
|positive regulation of cytokine production|
|regulation of innate immune response|
|ribonucleoprotein complex biogenesis|
|regulation of immune effector process|
|positive regulation of defense response|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|posttranscriptional regulation of gene expression|
|positive regulation of response to external stimulus|
|regulation of cytokine production|
|perinuclear region of cytoplasm|
|organelle assembly|
|regulation of defense response|
|regulation of multi-organism process|
|regulation of cellular catabolic process|
|cellular protein-containing complex assembly|
|positive regulation of immune response|
|RNA processing|
|regulation of catabolic process|
|positive regulation of intracellular signal transduction|
|regulation of response to external stimulus|
|regulation of immune response|
|positive regulation of immune system process|
|RNA binding|
|regulation of response to stress|
|protein-containing complex assembly|
|regulation of immune system process|
|positive regulation of signal transduction|
|RNA metabolic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-1.79|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|-1.79|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|-1.7|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|1.77|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.83|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15962
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.57 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PUM2 Expression in NALM6 Cells: 7.57'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>