PXDN

Entrez Summary: This gene encodes a heme-containing peroxidase that is secreted into the extracellular matrix. It is involved in extracellular matrix formation, and may function in the physiological and pathological fibrogenic response in fibrotic kidney. Mutations in this gene cause corneal opacification and other ocular anomalies, and also microphthalmia and anterior segment dysgenesis. [provided by RefSeq, Aug 2014].
UniProt Summary: Displays low peroxidase activity and is likely to participate in H(2)O(2) metabolism and peroxidative reactions in the cardiovascular system. Plays a role in extracellular matrix formation. {ECO:0000269|PubMed:18929642, ECO:0000269|PubMed:19590037}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

bromide peroxidase activity
interleukin-1 receptor antagonist activity
basement membrane assembly
basement membrane organization
hydrogen peroxide catabolic process
peroxidase activity
hydrogen peroxide metabolic process
collagen fibril organization
antibiotic catabolic process
negative regulation of cytokine-mediated signaling pathway
cofactor catabolic process
negative regulation of response to cytokine stimulus
cellular oxidant detoxification
cellular detoxification
antibiotic metabolic process
reactive oxygen species metabolic process
detoxification
extracellular matrix structural constituent
heme binding
drug catabolic process
regulation of cytokine-mediated signaling pathway
regulation of response to cytokine stimulus
cellular response to toxic substance
extracellular matrix organization
collagen-containing extracellular matrix
extracellular structure organization
response to oxidative stress
cofactor metabolic process
supramolecular fiber organization
drug metabolic process
response to toxic substance
oxidation-reduction process
endoplasmic reticulum
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
extracellular space
negative regulation of response to stimulus
cellular catabolic process
protein-containing complex subunit organization