PXDNL

Entrez Summary: N/A
UniProt Summary: Isoform PMR1: Endonuclease selectively degrading some target mRNAs while they are engaged by translating ribosomes, among which albumin and beta-globin mRNAs. {ECO:0000269|PubMed:22543864}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

hydrogen peroxide catabolic process
peroxidase activity
hydrogen peroxide metabolic process
endonuclease activity
antibiotic catabolic process
cofactor catabolic process
cellular oxidant detoxification
cellular detoxification
antibiotic metabolic process
reactive oxygen species metabolic process
detoxification
heme binding
drug catabolic process
cellular response to toxic substance
nucleic acid phosphodiester bond hydrolysis
response to oxidative stress
cofactor metabolic process
drug metabolic process
response to toxic substance
oxidation-reduction process
extracellular space
cellular catabolic process