PYDC2 [The Human Chemical-Genetic Interaction Map Project]

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======= PYDC2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PYDC2
  * **<color #00a2e8>Official Name</color>**: pyrin domain containing 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=152138|152138]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q56P42|Q56P42]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PYDC2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PYDC2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615701|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in innate immunity by disrupting the interaction between PYCARD and NLRP3, thereby regulating the NLRP3 inflammasome (PubMed:17339483, PubMed:17178784). May also inhibit NF-kappa-B signaling distally by affecting the nuclear accumulation of RELA (PubMed:17339483, PubMed:24871464). {ECO:0000269|PubMed:17178784, ECO:0000269|PubMed:17339483, ECO:0000269|PubMed:24871464}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PAAD DAPIN|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of NLRP3 inflammasome complex assembly|
|regulation of NLRP3 inflammasome complex assembly|
|negative regulation of interleukin-1 beta secretion|
|negative regulation of interleukin-1 secretion|
|negative regulation of tumor necrosis factor-mediated signaling pathway|
|negative regulation of NIK/NF-kappaB signaling|
|negative regulation of interleukin-1 beta production|
|negative regulation of interleukin-1 production|
|regulation of interleukin-1 beta secretion|
|regulation of interleukin-1 secretion|
|regulation of tumor necrosis factor-mediated signaling pathway|
|negative regulation of cytokine-mediated signaling pathway|
|negative regulation of response to cytokine stimulus|
|negative regulation of cytokine secretion|
|regulation of interleukin-1 beta production|
|negative regulation of NF-kappaB transcription factor activity|
|regulation of interleukin-1 production|
|regulation of NIK/NF-kappaB signaling|
|negative regulation of protein complex assembly|
|negative regulation of protein secretion|
|negative regulation of inflammatory response|
|negative regulation of peptide secretion|
|negative regulation of DNA-binding transcription factor activity|
|regulation of cytokine-mediated signaling pathway|
|regulation of response to cytokine stimulus|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|negative regulation of defense response|
|negative regulation of secretion|
|negative regulation of cytokine production|
|regulation of inflammatory response|
|negative regulation of response to external stimulus|
|regulation of DNA-binding transcription factor activity|
|regulation of protein complex assembly|
|regulation of protein secretion|
|negative regulation of transport|
|regulation of peptide secretion|
|inflammatory response|
|negative regulation of intracellular signal transduction|
|regulation of cytokine production|
|negative regulation of cellular component organization|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|innate immune response|
|regulation of secretion|
|defense response to other organism|
|regulation of cellular component biogenesis|
|regulation of protein localization|
|regulation of response to external stimulus|
|negative regulation of molecular function|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of response to stress|
|negative regulation of response to stimulus|
|regulation of intracellular signal transduction|
|regulation of transport|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|1.88|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|2.08|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16717
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PYDC2 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>