PYDC2

Gene Information

Official Symbol: PYDC2
Official Name: pyrin domain containing 2
Aliases and Previous Symbols: N/A
Entrez ID: 152138
UniProt: Q56P42
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: May play a role in innate immunity by disrupting the interaction between PYCARD and NLRP3, thereby regulating the NLRP3 inflammasome (PubMed:17339483, PubMed:17178784). May also inhibit NF-kappa-B signaling distally by affecting the nuclear accumulation of RELA (PubMed:17339483, PubMed:24871464). {ECO:0000269|PubMed:17178784, ECO:0000269|PubMed:17339483, ECO:0000269|PubMed:24871464}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6

Essentiality Rank: 16717
Expression level (log2 read counts): -7.68

Expression Distribution

Screen	Score
Taxol 0.002μM R01 exp54	1.88
BI-2536 0.001μM R01 exp41	2.08

negative regulation of NLRP3 inflammasome complex assembly
regulation of NLRP3 inflammasome complex assembly
negative regulation of interleukin-1 beta secretion
negative regulation of interleukin-1 secretion
negative regulation of tumor necrosis factor-mediated signaling pathway
negative regulation of NIK/NF-kappaB signaling
negative regulation of interleukin-1 beta production
negative regulation of interleukin-1 production
regulation of interleukin-1 beta secretion
regulation of interleukin-1 secretion
regulation of tumor necrosis factor-mediated signaling pathway
negative regulation of cytokine-mediated signaling pathway
negative regulation of response to cytokine stimulus
negative regulation of cytokine secretion
regulation of interleukin-1 beta production
negative regulation of NF-kappaB transcription factor activity
regulation of interleukin-1 production
regulation of NIK/NF-kappaB signaling
negative regulation of protein complex assembly
negative regulation of protein secretion
negative regulation of inflammatory response
negative regulation of peptide secretion
negative regulation of DNA-binding transcription factor activity
regulation of cytokine-mediated signaling pathway
regulation of response to cytokine stimulus
negative regulation of protein transport
negative regulation of establishment of protein localization
negative regulation of secretion by cell
regulation of cytokine secretion
negative regulation of defense response
negative regulation of secretion
negative regulation of cytokine production
regulation of inflammatory response
negative regulation of response to external stimulus
regulation of DNA-binding transcription factor activity
regulation of protein complex assembly
regulation of protein secretion
negative regulation of transport
regulation of peptide secretion
inflammatory response