PYGB

Entrez Summary: N/A
UniProt Summary: Glycogen phosphorylase that regulates glycogen mobilization (PubMed:27402852). Phosphorylase is an important allosteric enzyme in carbohydrate metabolism (PubMed:3346228). Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates (PubMed:3346228). However, all known phosphorylases share catalytic and structural properties (PubMed:3346228). {ECO:0000269|PubMed:27402852, ECO:0000303|PubMed:3346228}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

glycogen phosphorylase activity
linear malto-oligosaccharide phosphorylase activity
SHG alpha-glucan phosphorylase activity
glycogen catabolic process
glucan catabolic process
cellular polysaccharide catabolic process
polysaccharide catabolic process
cellular carbohydrate catabolic process
glycogen metabolic process
glucan metabolic process
cellular glucan metabolic process
pyridoxal phosphate binding
energy reserve metabolic process
cellular polysaccharide metabolic process
polysaccharide metabolic process
azurophil granule lumen
carbohydrate catabolic process
cellular carbohydrate metabolic process
energy derivation by oxidation of organic compounds
generation of precursor metabolites and energy
carbohydrate metabolic process
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
myeloid leukocyte activation
leukocyte activation involved in immune response
cell activation involved in immune response
regulated exocytosis
leukocyte mediated immunity
exocytosis
leukocyte activation
oxidation-reduction process
secretion by cell
export from cell
macromolecule catabolic process