PYGO1

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cisplatin 0.35μM R06 exp273	-2.37
Metformin 100 to 150μM on day4 R04 exp170	-1.79
Q15 1 to 2μM on day4 R04 exp164	-1.73
TIC10 10μM R08 exp532	-1.73
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	1.7

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

spermatid nucleus differentiation
beta-catenin-TCF complex assembly
methylated histone binding
hematopoietic progenitor cell differentiation
post-embryonic development
canonical Wnt signaling pathway
nucleus organization
spermatid development
spermatid differentiation
protein localization to nucleus
germ cell development
kidney development
renal system development
urogenital system development
cellular process involved in reproduction in multicellular organism
cell-cell signaling by wnt
Wnt signaling pathway
cell surface receptor signaling pathway involved in cell-cell signaling
spermatogenesis
hemopoiesis
male gamete generation
hematopoietic or lymphoid organ development
immune system development
developmental process involved in reproduction
gamete generation
protein localization to organelle
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
multi-organism reproductive process
cell-cell signaling
positive regulation of transcription by RNA polymerase II
reproductive process
reproduction
positive regulation of transcription, DNA-templated
protein-containing complex assembly
cellular protein localization
cellular macromolecule localization
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process