QDPR [The Human Chemical-Genetic Interaction Map Project]

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======= QDPR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: QDPR
  * **<color #00a2e8>Official Name</color>**: quinoid dihydropteridine reductase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5860|5860]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P09417|P09417]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=QDPR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20QDPR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612676|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the enzyme dihydropteridine reductase, which catalyzes the NADH-mediated reduction of quinonoid dihydrobiopterin.  This enzyme is an essential component of the pterin-dependent aromatic amino acid hydroxylating systems. Mutations in this gene resulting in QDPR deficiency include aberrant splicing, amino acid substitutions, insertions, or premature terminations.  Dihydropteridine reductase deficiency presents as atypical phenylketonuria due to insufficient production of biopterin, a cofactor for phenylalanine hydroxylase. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|6,7-dihydropteridine reductase activity|
|dihydrobiopterin metabolic process|
|NADH binding|
|response to aluminum ion|
|tetrahydrobiopterin biosynthetic process|
|tetrahydrobiopterin metabolic process|
|L-phenylalanine metabolic process|
|erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process|
|L-phenylalanine catabolic process|
|erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process|
|pteridine-containing compound biosynthetic process|
|NADPH binding|
|diol biosynthetic process|
|diol metabolic process|
|response to lead ion|
|aromatic amino acid family catabolic process|
|pteridine-containing compound metabolic process|
|response to glucagon|
|aromatic amino acid family metabolic process|
|polyol biosynthetic process|
|electron transfer activity|
|alpha-amino acid catabolic process|
|polyol metabolic process|
|alcohol biosynthetic process|
|cellular amino acid catabolic process|
|liver development|
|hepaticobiliary system development|
|coenzyme biosynthetic process|
|drug catabolic process|
|electron transport chain|
|organic hydroxy compound biosynthetic process|
|alpha-amino acid metabolic process|
|cofactor biosynthetic process|
|coenzyme metabolic process|
|carboxylic acid catabolic process|
|organic acid catabolic process|
|cellular amino acid metabolic process|
|alcohol metabolic process|
|neuron projection|
|response to metal ion|
|response to peptide hormone|
|cellular response to drug|
|gland development|
|generation of precursor metabolites and energy|
|small molecule catabolic process|
|cofactor metabolic process|
|aromatic compound catabolic process|
|organic hydroxy compound metabolic process|
|response to peptide|
|organic cyclic compound catabolic process|
|drug metabolic process|
|response to inorganic substance|
|small molecule biosynthetic process|
|protein homodimerization activity|
|carboxylic acid metabolic process|
|response to hormone|
|oxidation-reduction process|
|response to organonitrogen compound|
|oxoacid metabolic process|
|response to drug|
|organic acid metabolic process|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.97|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-2.04|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|-2.03|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-1.74|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|-1.71|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|1.95|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.95|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11299
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='QDPR Expression in NALM6 Cells: 4.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>