QDPR

Entrez Summary: This gene encodes the enzyme dihydropteridine reductase, which catalyzes the NADH-mediated reduction of quinonoid dihydrobiopterin. This enzyme is an essential component of the pterin-dependent aromatic amino acid hydroxylating systems. Mutations in this gene resulting in QDPR deficiency include aberrant splicing, amino acid substitutions, insertions, or premature terminations. Dihydropteridine reductase deficiency presents as atypical phenylketonuria due to insufficient production of biopterin, a cofactor for phenylalanine hydroxylase. [provided by RefSeq, Jul 2008].
UniProt Summary: The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

6,7-dihydropteridine reductase activity
dihydrobiopterin metabolic process
NADH binding
response to aluminum ion
tetrahydrobiopterin biosynthetic process
tetrahydrobiopterin metabolic process
L-phenylalanine metabolic process
erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process
L-phenylalanine catabolic process
erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process
pteridine-containing compound biosynthetic process
NADPH binding
diol biosynthetic process
diol metabolic process
response to lead ion
aromatic amino acid family catabolic process
pteridine-containing compound metabolic process
response to glucagon
aromatic amino acid family metabolic process
polyol biosynthetic process
electron transfer activity
alpha-amino acid catabolic process
polyol metabolic process
alcohol biosynthetic process
cellular amino acid catabolic process
liver development
hepaticobiliary system development
coenzyme biosynthetic process
drug catabolic process
electron transport chain
organic hydroxy compound biosynthetic process
alpha-amino acid metabolic process
cofactor biosynthetic process
coenzyme metabolic process
carboxylic acid catabolic process
organic acid catabolic process
cellular amino acid metabolic process
alcohol metabolic process
neuron projection
response to metal ion