QKI [The Human Chemical-Genetic Interaction Map Project]

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======= QKI =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: QKI
  * **<color #00a2e8>Official Name</color>**: QKI, KH domain containing RNA binding
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9444|9444]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96PU8|Q96PU8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=QKI&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20QKI|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609590|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. The encoded protein is involved in myelinization and oligodendrocyte differentiation and may play a role in schizophrenia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|long-chain fatty acid biosynthetic process|
|vasculogenesis|
|myelination|
|ensheathment of neurons|
|axon ensheathment|
|long-chain fatty acid metabolic process|
|fatty acid biosynthetic process|
|SH3 domain binding|
|spermatid development|
|mRNA transport|
|spermatid differentiation|
|mRNA binding|
|monocarboxylic acid biosynthetic process|
|RNA transport|
|nucleic acid transport|
|establishment of RNA localization|
|RNA localization|
|nucleobase-containing compound transport|
|muscle cell differentiation|
|germ cell development|
|synapse|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|fatty acid metabolic process|
|regulation of translation|
|cellular process involved in reproduction in multicellular organism|
|RNA splicing|
|regulation of cellular amide metabolic process|
|blood vessel morphogenesis|
|muscle structure development|
|mRNA processing|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|posttranscriptional regulation of gene expression|
|monocarboxylic acid metabolic process|
|spermatogenesis|
|male gamete generation|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|tube morphogenesis|
|developmental process involved in reproduction|
|gamete generation|
|mRNA metabolic process|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|tube development|
|circulatory system development|
|RNA processing|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|multi-organism reproductive process|
|oxoacid metabolic process|
|organic acid metabolic process|
|lipid metabolic process|
|RNA binding|
|reproductive process|
|reproduction|
|cell development|
|RNA metabolic process|
|small molecule metabolic process|
|nitrogen compound transport|
|positive regulation of gene expression|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-2.04|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-1.97|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-1.95|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|-1.95|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.95|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-1.74|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|1.7|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|1.71|
|[[:results:exp483|FTY720 3μM R08 exp483]]|1.77|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|1.8|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|1.84|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|1.9|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.92|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|3|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:f:fam122a|FAM122A]]|0.411|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17049
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='QKI Expression in NALM6 Cells: 6.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>