QKI

Entrez Summary: The protein encoded by this gene is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. The encoded protein is involved in myelinization and oligodendrocyte differentiation and may play a role in schizophrenia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Colchicine 0.009μM R05 exp215	-2.04
BVD-523 15μM R02 exp67	-1.97
3-Bromopyruvate 7μM R04 exp175	-1.95
UM0011500 10μM R05 exp246	-1.95
UM131593 0.2μM R03 exp106	-1.95
Rotenone 0.07μM R08 exp431	-1.74
Lead acetate 2000μM R08 exp498 no dilution day6	1.7
Ribavirin 10 to 15μM on day4 R04 exp160	1.71
FTY720 3μM R08 exp483	1.77
Pomalidomide 20μM R07 exp391	1.8
ETC-159 50μM R08 exp480	1.84
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	1.9
Tubacin 1.6μM R07 exp416	2.92
Dynasore 10μM R04 exp180	3

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

long-chain fatty acid biosynthetic process
vasculogenesis
myelination
ensheathment of neurons
axon ensheathment
long-chain fatty acid metabolic process
fatty acid biosynthetic process
SH3 domain binding
spermatid development
mRNA transport
spermatid differentiation
mRNA binding
monocarboxylic acid biosynthetic process
RNA transport
nucleic acid transport
establishment of RNA localization
RNA localization
nucleobase-containing compound transport
muscle cell differentiation
germ cell development
synapse
carboxylic acid biosynthetic process
organic acid biosynthetic process
fatty acid metabolic process
regulation of translation
cellular process involved in reproduction in multicellular organism
RNA splicing
regulation of cellular amide metabolic process
blood vessel morphogenesis
muscle structure development
mRNA processing
blood vessel development
vasculature development
cardiovascular system development
posttranscriptional regulation of gene expression
monocarboxylic acid metabolic process
spermatogenesis
male gamete generation
lipid biosynthetic process
small molecule biosynthetic process