RAB11FIP4

Entrez Summary: The protein encoded by this gene interacts with RAB11 and is thought to be involved in bringing recycling endosome membranes to the cleavage furrow in late cytokinesis. Hypoxic conditions can lead to an upregulation of the encoded protein and enhance the metastatic potential of hepatocellular carcinoma. [provided by RefSeq, Oct 2016].
UniProt Summary: Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6. {ECO:0000269|PubMed:12470645}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of G1 to G0 transition
regulation of G1 to G0 transition
ADP-ribosylation factor binding
endocytic recycling
cleavage furrow
neural retina development
endocytic vesicle
recycling endosome membrane
regulation of cytokinesis
spindle
retina development in camera-type eye
Rab GTPase binding
midbody
regulation of cell division
endosomal transport
endosome
positive regulation of cell cycle process
camera-type eye development
eye development
visual system development
sensory system development
positive regulation of cell cycle
centrosome
sensory organ development
perinuclear region of cytoplasm
viral process
calcium ion binding
regulation of cell cycle process
symbiotic process
interspecies interaction between organisms
protein homodimerization activity
regulation of cell cycle
intracellular transport
extracellular space
establishment of localization in cell
vesicle-mediated transport