RAB12

Entrez Summary: N/A
UniProt Summary: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

endosome to lysosome transport
phagocytic vesicle
positive regulation of macroautophagy
autophagosome
Rab protein signal transduction
GDP binding
recycling endosome membrane
lysosomal transport
positive regulation of autophagy
vacuolar transport
cellular response to interferon-gamma
trans-Golgi network
regulation of macroautophagy
response to interferon-gamma
endoplasmic reticulum to Golgi vesicle-mediated transport
Ras protein signal transduction
lysosome
autophagy
process utilizing autophagic mechanism
lysosomal membrane
small GTPase mediated signal transduction
GTPase activity
regulation of autophagy
positive regulation of cellular catabolic process
Golgi vesicle transport
GTP binding
positive regulation of catabolic process
cellular protein catabolic process
Golgi membrane
protein catabolic process
innate immune response
regulation of cellular catabolic process
cellular macromolecule catabolic process
endoplasmic reticulum membrane
defense response to other organism
regulation of catabolic process
intracellular protein transport
cellular response to cytokine stimulus
macromolecule catabolic process
organonitrogen compound catabolic process