RAB25

Entrez Summary: N/A
UniProt Summary: Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia (PubMed:17925226). Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions (By similarity). May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis (By similarity). {ECO:0000250|UniProtKB:E2RQ15, ECO:0000250|UniProtKB:P46629, ECO:0000250|UniProtKB:Q9WTL2, ECO:0000269|PubMed:17925226}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

pseudopodium membrane
pseudopodium organization
myosin V binding
pseudopodium
epithelial cell morphogenesis
Rab protein signal transduction
recycling endosome
positive regulation of epithelial cell migration
epithelial cell development
regulation of epithelial cell migration
Ras protein signal transduction
cytoplasmic vesicle
endosome
small GTPase mediated signal transduction
GTPase activity
GTP binding
positive regulation of cell migration
positive regulation of cell motility
positive regulation of cellular component movement
regulation of vesicle-mediated transport
positive regulation of locomotion
cell morphogenesis involved in differentiation
epithelial cell differentiation
cell morphogenesis
exocytosis
cellular component morphogenesis
regulation of cell migration
regulation of cell motility
positive regulation of cell population proliferation
regulation of locomotion
intracellular protein transport
regulation of cellular component movement
secretion by cell
export from cell
epithelium development
secretion
plasma membrane bounded cell projection organization
cell projection organization
protein transport
intracellular transport