RAB27A [The Human Chemical-Genetic Interaction Map Project]

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======= RAB27A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAB27A
  * **<color #00a2e8>Official Name</color>**: RAB27A, member RAS oncogene family
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5873|5873]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P51159|P51159]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAB27A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAB27A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603868|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. {ECO:0000269|PubMed:18812475}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ras|
|Arf|
|Miro|
|GTP EFTU|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of constitutive secretory pathway|
|cytotoxic T cell degranulation|
|complement-dependent cytotoxicity|
|regulation of constitutive secretory pathway|
|exosomal secretion|
|Weibel-Palade body|
|extracellular exosome biogenesis|
|natural killer cell degranulation|
|extracellular vesicle biogenesis|
|multivesicular body membrane|
|melanosome membrane|
|myosin V binding|
|T cell mediated cytotoxicity|
|melanosome transport|
|melanocyte differentiation|
|pigment granule transport|
|establishment of melanosome localization|
|establishment of pigment granule localization|
|melanosome localization|
|natural killer cell activation involved in immune response|
|pigment granule localization|
|natural killer cell mediated cytotoxicity|
|exocytic vesicle|
|natural killer cell mediated immunity|
|multivesicular body organization|
|pigment cell differentiation|
|multivesicular body sorting pathway|
|synaptic vesicle transport|
|developmental pigmentation|
|synaptic vesicle localization|
|leukocyte mediated cytotoxicity|
|T cell mediated immunity|
|cellular pigmentation|
|positive regulation of reactive oxygen species biosynthetic process|
|positive regulation of regulated secretory pathway|
|natural killer cell activation|
|photoreceptor outer segment|
|specific granule lumen|
|T cell activation involved in immune response|
|positive regulation of phagocytosis|
|Rab protein signal transduction|
|GDP binding|
|endosome organization|
|regulation of reactive oxygen species biosynthetic process|
|secretory granule|
|positive regulation of exocytosis|
|cell killing|
|pigmentation|
|regulation of phagocytosis|
|positive regulation of reactive oxygen species metabolic process|
|secretory granule membrane|
|melanosome|
|lymphocyte activation involved in immune response|
|late endosome|
|regulation of regulated secretory pathway|
|establishment of vesicle localization|
|regulation of reactive oxygen species metabolic process|
|vesicle localization|
|antigen processing and presentation|
|regulation of exocytosis|
|T cell activation|
|protein domain specific binding|
|Ras protein signal transduction|
|lysosome|
|lymphocyte mediated immunity|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|blood coagulation|
|coagulation|
|hemostasis|
|vesicle organization|
|apical plasma membrane|
|small GTPase mediated signal transduction|
|GTPase activity|
|protein targeting|
|establishment of organelle localization|
|lymphocyte activation|
|GTP binding|
|positive regulation of secretion by cell|
|endomembrane system organization|
|dendrite|
|positive regulation of secretion|
|wound healing|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|regulation of body fluid levels|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|regulation of vesicle-mediated transport|
|response to wounding|
|organelle localization|
|myeloid leukocyte activation|
|adaptive immune response|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulated exocytosis|
|regulation of secretion by cell|
|leukocyte mediated immunity|
|innate immune response|
|exocytosis|
|regulation of secretion|
|leukocyte activation|
|defense response to other organism|
|Golgi apparatus|
|positive regulation of transport|
|intracellular protein transport|
|secretion by cell|
|export from cell|
|cell activation|
|immune effector process|
|secretion|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.97|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|-1.86|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|-1.78|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-1.72|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|1.73|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|1.75|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|1.76|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|1.89|
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|2.4|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16760
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAB27A Expression in NALM6 Cells: 4.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>