RAB27A

Entrez Summary: The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008].
UniProt Summary: Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. {ECO:0000269|PubMed:18812475}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Aminopterin 0.005μM R07 exp335	-1.97
Phenformin 20μM R03 exp143	-1.86
LB-100 4.1μM R02 exp72	-1.78
Hippuristanol 0.12μM R08 exp489 no dilution day6	-1.72
Cryptotanshinone 12μM R05 exp227	1.73
Tunicamycin 0.04μM R07 exp418	1.75
Nicotine 3000μM R08 exp510	1.76
Geldanamycin 0.01μM R05 exp235	1.89
Aphidicolin 0.04μM R06 exp263	2.4

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of constitutive secretory pathway
cytotoxic T cell degranulation
complement-dependent cytotoxicity
regulation of constitutive secretory pathway
exosomal secretion
Weibel-Palade body
extracellular exosome biogenesis
natural killer cell degranulation
extracellular vesicle biogenesis
multivesicular body membrane
melanosome membrane
myosin V binding
T cell mediated cytotoxicity
melanosome transport
melanocyte differentiation
pigment granule transport
establishment of melanosome localization
establishment of pigment granule localization
melanosome localization
natural killer cell activation involved in immune response
pigment granule localization
natural killer cell mediated cytotoxicity
exocytic vesicle
natural killer cell mediated immunity
multivesicular body organization
pigment cell differentiation
multivesicular body sorting pathway
synaptic vesicle transport
developmental pigmentation
synaptic vesicle localization
leukocyte mediated cytotoxicity
T cell mediated immunity
cellular pigmentation
positive regulation of reactive oxygen species biosynthetic process
positive regulation of regulated secretory pathway
natural killer cell activation
photoreceptor outer segment
specific granule lumen
T cell activation involved in immune response
positive regulation of phagocytosis