RAB32

Entrez Summary: N/A
UniProt Summary: Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission (PubMed:12186851). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays an important role in the control of melanin production and melanosome biogenesis (PubMed:23084991). In concert with RAB38, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity). {ECO:0000250|UniProtKB:Q9CZE3, ECO:0000269|PubMed:12186851, ECO:0000269|PubMed:21255211, ECO:0000269|PubMed:23084991}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

BLOC-2 complex binding
AP-3 adaptor complex binding
AP-1 adaptor complex binding
early endosome lumen
melanosome assembly
AP-2 adaptor complex binding
endosome to pigment granule transport
endosome to melanosome transport
pigment granule maturation
pigment accumulation
cellular pigment accumulation
mitochondria-associated endoplasmic reticulum membrane
melanosome membrane
GTP-dependent protein binding
melanosome organization
pigment granule organization
pigment cell differentiation
developmental pigmentation
phagosome maturation
cellular pigmentation
phagocytic vesicle
Rab protein signal transduction
phagocytic vesicle membrane
pigmentation
melanosome
mitochondrial outer membrane
trans-Golgi network
antigen processing and presentation
developmental maturation
Ras protein signal transduction
early endosome
vesicle organization
small GTPase mediated signal transduction
GTPase activity
GTP binding
mitochondrion organization
protein localization to membrane
organelle assembly
intracellular protein transport
endoplasmic reticulum