RAB3A [The Human Chemical-Genetic Interaction Map Project]

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======= RAB3A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAB3A
  * **<color #00a2e8>Official Name</color>**: RAB3A, member RAS oncogene family
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5864|5864]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P20336|P20336]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAB3A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAB3A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/179490|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ras|
|Arf|
|Miro|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|evoked neurotransmitter secretion|
|GDP-dissociation inhibitor binding|
|constitutive secretory pathway|
|clathrin-sculpted acetylcholine transport vesicle membrane|
|regulation of plasma membrane repair|
|clathrin-sculpted glutamate transport vesicle membrane|
|sensory perception of touch|
|clathrin-sculpted monoamine transport vesicle membrane|
|maintenance of presynaptic active zone structure|
|acrosomal vesicle exocytosis|
|presynaptic active zone organization|
|regulation of synaptic vesicle priming|
|clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane|
|synaptic vesicle clustering|
|regulation of synaptic vesicle fusion to presynaptic active zone membrane|
|synaptic vesicle maturation|
|plasma membrane repair|
|respiratory system process|
|anchored component of synaptic vesicle membrane|
|regulation of short-term neuronal synaptic plasticity|
|maintenance of synapse structure|
|regulation of plasma membrane organization|
|myosin V binding|
|GTP-dependent protein binding|
|acrosome reaction|
|ATPase activator activity|
|glutamate secretion|
|regulation of vesicle fusion|
|neuromuscular synaptic transmission|
|synaptic vesicle transport|
|presynaptic active zone|
|synaptic vesicle localization|
|calcium-ion regulated exocytosis|
|vesicle docking involved in exocytosis|
|respiratory gaseous exchange by respiratory system|
|response to electrical stimulus|
|lysosome localization|
|cellular component maintenance|
|acidic amino acid transport|
|terminal bouton|
|synaptic vesicle recycling|
|regulation of neuronal synaptic plasticity|
|positive regulation of regulated secretory pathway|
|positive regulation of ATPase activity|
|extracellular vesicle|
|vesicle docking|
|synaptic vesicle exocytosis|
|exocytic process|
|Rab protein signal transduction|
|regulation of synaptic vesicle exocytosis|
|dicarboxylic acid transport|
|acid secretion|
|ATPase binding|
|regulation of ATPase activity|
|acrosomal vesicle|
|post-embryonic development|
|positive regulation of exocytosis|
|plasma membrane organization|
|secretory granule membrane|
|signal release from synapse|
|neurotransmitter secretion|
|regulation of neurotransmitter secretion|
|regulation of synaptic vesicle cycle|
|amino acid transport|
|synaptic vesicle cycle|
|synaptic vesicle|
|vesicle-mediated transport in synapse|
|regulation of wound healing|
|single fertilization|
|vesicle|
|regulation of neurotransmitter transport|
|protein secretion|
|establishment of protein localization to extracellular region|
|regulation of regulated secretory pathway|
|protein localization to extracellular region|
|regulation of response to wounding|
|sensory perception of mechanical stimulus|
|signal release|
|lung development|
|organelle localization by membrane tethering|
|fertilization|
|respiratory tube development|
|peptide secretion|
|establishment of vesicle localization|
|membrane docking|
|neurotransmitter transport|
|protein localization to plasma membrane|
|vesicle localization|
|regulation of synaptic plasticity|
|protein C-terminus binding|
|respiratory system development|
|regulation of exocytosis|
|protein localization to cell periphery|
|developmental maturation|
|Ras protein signal transduction|
|lysosome|
|endosome|
|synapse organization|
|organic acid transport|
|carboxylic acid transport|
|axon|
|vesicle organization|
|small GTPase mediated signal transduction|
|GTPase activity|
|regulation of neurotransmitter levels|
|post-translational protein modification|
|establishment of organelle localization|
|axonogenesis|
|GTP binding|
|positive regulation of secretion by cell|
|axon development|
|endomembrane system organization|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|cell morphogenesis involved in neuron differentiation|
|positive regulation of secretion|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|mitochondrion organization|
|regulation of trans-synaptic signaling|
|regulation of protein complex assembly|
|organic anion transport|
|synaptic signaling|
|wound healing|
|protein localization to membrane|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|neutrophil degranulation|
|cell projection morphogenesis|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|cell part morphogenesis|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|regulation of vesicle-mediated transport|
|cell morphogenesis involved in differentiation|
|response to wounding|
|organelle localization|
|anion transport|
|myeloid leukocyte activation|
|protein-containing complex|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|neuron projection development|
|perinuclear region of cytoplasm|
|regulated exocytosis|
|cell morphogenesis|
|regulation of secretion by cell|
|leukocyte mediated immunity|
|positive regulation of hydrolase activity|
|exocytosis|
|regulation of secretion|
|neuron development|
|cellular component morphogenesis|
|sexual reproduction|
|tube development|
|membrane organization|
|regulation of cellular localization|
|leukocyte activation|
|regulation of cellular component biogenesis|
|sensory perception|
|positive regulation of transport|
|intracellular protein transport|
|multi-organism reproductive process|
|secretion by cell|
|neuron differentiation|
|export from cell|
|cell activation|
|immune effector process|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|secretion|
|cell projection organization|
|response to abiotic stimulus|
|regulation of hydrolase activity|
|regulation of organelle organization|
|ion transport|
|nervous system process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|cell development|
|intracellular signal transduction|
|positive regulation of molecular function|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11749
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAB3A Expression in NALM6 Cells: 2.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>