RAB3A
Gene Information
- Official Symbol: RAB3A
- Official Name: RAB3A, member RAS oncogene family
- Aliases and Previous Symbols: N/A
- Entrez ID: 5864
- UniProt: P20336
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal.
Pfam Domains GO Terms
Pfam Domains
| Ras |
| Arf |
| Miro |
GO Terms
| evoked neurotransmitter secretion |
| GDP-dissociation inhibitor binding |
| constitutive secretory pathway |
| clathrin-sculpted acetylcholine transport vesicle membrane |
| regulation of plasma membrane repair |
| clathrin-sculpted glutamate transport vesicle membrane |
| sensory perception of touch |
| clathrin-sculpted monoamine transport vesicle membrane |
| maintenance of presynaptic active zone structure |
| acrosomal vesicle exocytosis |
| presynaptic active zone organization |
| regulation of synaptic vesicle priming |
| clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane |
| synaptic vesicle clustering |
| regulation of synaptic vesicle fusion to presynaptic active zone membrane |
| synaptic vesicle maturation |
| plasma membrane repair |
| respiratory system process |
| anchored component of synaptic vesicle membrane |
| regulation of short-term neuronal synaptic plasticity |
| maintenance of synapse structure |
| regulation of plasma membrane organization |
| myosin V binding |
| GTP-dependent protein binding |
| acrosome reaction |
| ATPase activator activity |
| glutamate secretion |
| regulation of vesicle fusion |
| neuromuscular synaptic transmission |
| synaptic vesicle transport |
| presynaptic active zone |
| synaptic vesicle localization |
| calcium-ion regulated exocytosis |
| vesicle docking involved in exocytosis |
| respiratory gaseous exchange by respiratory system |
| response to electrical stimulus |
| lysosome localization |
| cellular component maintenance |
| acidic amino acid transport |
| terminal bouton |
| synaptic vesicle recycling |
| regulation of neuronal synaptic plasticity |
| positive regulation of regulated secretory pathway |
| positive regulation of ATPase activity |
| extracellular vesicle |
| vesicle docking |
| synaptic vesicle exocytosis |
| exocytic process |
| Rab protein signal transduction |
| regulation of synaptic vesicle exocytosis |
| dicarboxylic acid transport |
| acid secretion |
| ATPase binding |
| regulation of ATPase activity |
| acrosomal vesicle |
| post-embryonic development |
| positive regulation of exocytosis |
| plasma membrane organization |
| secretory granule membrane |
| signal release from synapse |
| neurotransmitter secretion |
| regulation of neurotransmitter secretion |
| regulation of synaptic vesicle cycle |
| amino acid transport |
| synaptic vesicle cycle |
| synaptic vesicle |
| vesicle-mediated transport in synapse |
| regulation of wound healing |
| single fertilization |
| vesicle |
| regulation of neurotransmitter transport |
| protein secretion |
| establishment of protein localization to extracellular region |
| regulation of regulated secretory pathway |
| protein localization to extracellular region |
| regulation of response to wounding |
| sensory perception of mechanical stimulus |
| signal release |
| lung development |
| organelle localization by membrane tethering |
| fertilization |
| respiratory tube development |
| peptide secretion |
| establishment of vesicle localization |
| membrane docking |
| neurotransmitter transport |
| protein localization to plasma membrane |
| vesicle localization |
| regulation of synaptic plasticity |
| protein C-terminus binding |
| respiratory system development |
| regulation of exocytosis |
| protein localization to cell periphery |
| developmental maturation |
| Ras protein signal transduction |
| lysosome |
| endosome |
| synapse organization |
| organic acid transport |
| carboxylic acid transport |
| axon |
| vesicle organization |
| small GTPase mediated signal transduction |
| GTPase activity |
| regulation of neurotransmitter levels |
| post-translational protein modification |
| establishment of organelle localization |
| axonogenesis |
| GTP binding |
| positive regulation of secretion by cell |
| axon development |
| endomembrane system organization |
| anterograde trans-synaptic signaling |
| chemical synaptic transmission |
| cell morphogenesis involved in neuron differentiation |
| positive regulation of secretion |
| trans-synaptic signaling |
| modulation of chemical synaptic transmission |
| mitochondrion organization |
| regulation of trans-synaptic signaling |
| regulation of protein complex assembly |
| organic anion transport |
| synaptic signaling |
| wound healing |
| protein localization to membrane |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| neutrophil degranulation |
| cell projection morphogenesis |
| neutrophil activation involved in immune response |
| neutrophil mediated immunity |
| neutrophil activation |
| granulocyte activation |
| leukocyte degranulation |
| cell part morphogenesis |
| myeloid leukocyte mediated immunity |
| myeloid cell activation involved in immune response |
| regulation of vesicle-mediated transport |
| cell morphogenesis involved in differentiation |
| response to wounding |
| organelle localization |
| anion transport |
| myeloid leukocyte activation |
| protein-containing complex |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| neuron projection development |
| perinuclear region of cytoplasm |
| regulated exocytosis |
| cell morphogenesis |
| regulation of secretion by cell |
| leukocyte mediated immunity |
| positive regulation of hydrolase activity |
| exocytosis |
| regulation of secretion |
| neuron development |
| cellular component morphogenesis |
| sexual reproduction |
| tube development |
| membrane organization |
| regulation of cellular localization |
| leukocyte activation |
| regulation of cellular component biogenesis |
| sensory perception |
| positive regulation of transport |
| intracellular protein transport |
| multi-organism reproductive process |
| secretion by cell |
| neuron differentiation |
| export from cell |
| cell activation |
| immune effector process |
| cell-cell signaling |
| plasma membrane bounded cell projection organization |
| secretion |
| cell projection organization |
| response to abiotic stimulus |
| regulation of hydrolase activity |
| regulation of organelle organization |
| ion transport |
| nervous system process |
| reproductive process |
| reproduction |
| positive regulation of catalytic activity |
| regulation of response to stress |
| protein transport |
| intracellular transport |
| generation of neurons |
| peptide transport |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| neurogenesis |
| cell development |
| intracellular signal transduction |
| positive regulation of molecular function |
| establishment of localization in cell |
| nitrogen compound transport |
| regulation of transport |
| immune response |
| vesicle-mediated transport |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 11749
- Expression level (log2 read counts): 2.37
Expression Distribution
RAB3A Expression in NALM6 Cells: 2.37
