RAC3

Entrez Summary: N/A
UniProt Summary: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Promotes cell adhesion and spreading on fibrinogen in a CIB1 and alpha-IIb/beta3 integrin-mediated manner. {ECO:0000269|PubMed:11756406, ECO:0000269|PubMed:11956649}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cerebral cortex GABAergic interneuron development
regulation of neuron maturation
cerebral cortex GABAergic interneuron differentiation
engulfment of apoptotic cell
GABAergic neuron differentiation
synaptic transmission, GABAergic
positive regulation of cell adhesion mediated by integrin
regulation of cell maturation
cerebral cortex neuron differentiation
homeostasis of number of cells within a tissue
forebrain neuron development
filamentous actin
positive regulation of substrate adhesion-dependent cell spreading
cell periphery
apoptotic cell clearance
regulation of cell adhesion mediated by integrin
forebrain neuron differentiation
neuromuscular process controlling balance
regulation of substrate adhesion-dependent cell spreading
calcium-dependent protein binding
actin cytoskeleton reorganization
forebrain generation of neurons
endomembrane system
Rho protein signal transduction
central nervous system neuron development
positive regulation of actin filament polymerization
cell projection
neuromuscular process
positive regulation of cell-substrate adhesion
positive regulation of protein polymerization
growth cone
phagocytosis, engulfment
plasma membrane invagination
membrane invagination
positive regulation of cell morphogenesis involved in differentiation
regulation of actin filament polymerization
central nervous system neuron differentiation
lamellipodium
regulation of actin polymerization or depolymerization
regulation of actin filament length