RAD18

Entrez Summary: N/A
UniProt Summary: E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap- filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono- ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity. {ECO:0000269|PubMed:17108083, ECO:0000269|PubMed:21659603}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Olaparib 4μM R08 exp512	-1.95
GSK-J4 1μM R07 exp362	-1.81
Diepoxybutane 3μM R07 exp354	1.71
Nicotine 3000μM R08 exp510	1.74
Hippuristanol 0.12μM R08 exp489 no dilution day6	1.86
Nutlin-3A 1.6μM R06 exp294	2.47

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

SAP
zf-C3HC4

Rad6-Rad18 complex
Y-form DNA binding
nuclear inclusion body
single-stranded DNA helicase activity
replication fork
positive regulation of chromosome segregation
polyubiquitin modification-dependent protein binding
DNA damage response, detection of DNA damage
postreplication repair
damaged DNA binding
site of double-strand break
protein monoubiquitination
protein autoubiquitination
regulation of chromosome segregation
single-stranded DNA binding
DNA duplex unwinding
DNA geometric change
response to UV
ubiquitin protein ligase activity
protein-containing complex binding
nuclear body
ubiquitin protein ligase binding
DNA conformation change
response to light stimulus
response to radiation
centrosome
DNA repair
protein ubiquitination
detection of stimulus
DNA metabolic process
protein modification by small protein conjugation
cellular response to DNA damage stimulus
protein modification by small protein conjugation or removal
negative regulation of cell death
chromosome organization
identical protein binding
response to abiotic stimulus
regulation of cell death
cellular response to stress