RAD54B
Gene Information
- Official Symbol: RAD54B
- Official Name: RAD54 homolog B
- Aliases and Previous Symbols: N/A
- Entrez ID: 25788
- UniProt: Q9Y620
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene belongs to the DEAD-like helicase superfamily. It shares similarity with Saccharomyces cerevisiae RAD54 and RDH54, both of which are involved in homologous recombination and repair of DNA. This protein binds to double-stranded DNA, and displays ATPase activity in the presence of DNA. This gene is highly expressed in testis and spleen, which suggests active roles in meiotic and mitotic recombination. Homozygous mutations of this gene were observed in primary lymphoma and colon cancer. [provided by RefSeq, Jul 2008].
- UniProt Summary: Involved in DNA repair and mitotic recombination. May play an active role in recombination processes in concert with other members of the RAD52 epistasis group. {ECO:0000269|PubMed:11782437, ECO:0000269|PubMed:11884632}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 11682
- Expression level (log2 read counts): 3.65
RAD54B Expression in NALM6 Cells: 3.65
