RAET1G

Gene Information

Official Symbol: RAET1G
Official Name: retinoic acid early transcript 1G
Aliases and Previous Symbols: N/A
Entrez ID: 353091
UniProt: Q6H3X3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Isoform 1: Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. {ECO:0000269|PubMed:15240696, ECO:0000269|PubMed:18544572, ECO:0000269|PubMed:19658097}. Isoform 2: Stimulates natural killer cells to secrete IFNG. {ECO:0000269|PubMed:18544572}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12170
Expression level (log2 read counts): -0.02

Expression Distribution

Screen	Score
Ribavirin 10 to 15μM on day4 R04 exp160	-2.2
Docetaxel 0.002μM R01 exp45	-2.18
Q15 1 to 2μM on day4 R04 exp164	-2.08

positive regulation of natural killer cell cytokine production
regulation of natural killer cell cytokine production
natural killer cell lectin-like receptor binding
susceptibility to natural killer cell mediated cytotoxicity
T cell mediated cytotoxicity
natural killer cell mediated cytotoxicity
natural killer cell mediated immunity
positive regulation of natural killer cell mediated cytotoxicity
positive regulation of natural killer cell mediated immunity
leukocyte mediated cytotoxicity
T cell mediated immunity
regulation of natural killer cell mediated cytotoxicity
regulation of natural killer cell mediated immunity
positive regulation of cytokine production involved in immune response
positive regulation of leukocyte mediated cytotoxicity
natural killer cell activation
positive regulation of cell killing
regulation of leukocyte mediated cytotoxicity
regulation of cytokine production involved in immune response
cell killing
positive regulation of production of molecular mediator of immune response
regulation of cell killing
anchored component of membrane
positive regulation of lymphocyte mediated immunity
positive regulation of leukocyte mediated immunity
regulation of production of molecular mediator of immune response
regulation of lymphocyte mediated immunity
regulation of leukocyte mediated immunity
positive regulation of immune effector process
lymphocyte mediated immunity
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
positive regulation of innate immune response
positive regulation of response to biotic stimulus
lymphocyte activation
external side of plasma membrane
positive regulation of cytokine production
regulation of innate immune response
regulation of immune effector process
positive regulation of defense response
positive regulation of multi-organism process