RAMP2
Gene Information
- Official Symbol: RAMP2
- Official Name: receptor activity modifying protein 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 10266
- UniProt: O60895
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL. {ECO:0000269|PubMed:22102369, ECO:0000269|PubMed:9620797}.
Pfam Domains GO Terms
Pfam Domains
| RAMP |
GO Terms
| adrenomedullin binding |
| amylin receptor complex 2 |
| adrenomedullin receptor activity |
| adrenomedullin receptor complex |
| adrenomedullin receptor signaling pathway |
| amylin receptor activity |
| amylin receptor signaling pathway |
| calcitonin family receptor signaling pathway |
| basement membrane assembly |
| vascular smooth muscle cell development |
| positive regulation of vasculogenesis |
| negative regulation of vascular permeability |
| vascular smooth muscle cell differentiation |
| regulation of vasculogenesis |
| basement membrane organization |
| negative regulation of endothelial cell apoptotic process |
| smooth muscle cell differentiation |
| coreceptor activity |
| adherens junction assembly |
| regulation of vascular permeability |
| bicellular tight junction assembly |
| tight junction assembly |
| tight junction organization |
| cellular response to vascular endothelial growth factor stimulus |
| negative regulation of epithelial cell apoptotic process |
| response to progesterone |
| apical junction assembly |
| regulation of endothelial cell apoptotic process |
| clathrin-coated pit |
| sprouting angiogenesis |
| receptor internalization |
| vasculogenesis |
| regulation of epithelial cell apoptotic process |
| cell |
| adherens junction organization |
| receptor metabolic process |
| cell-cell junction assembly |
| adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| response to estradiol |
| cell-cell junction organization |
| regulation of G protein-coupled receptor signaling pathway |
| cAMP-mediated signaling |
| muscle cell development |
| positive regulation of angiogenesis |
| cell junction assembly |
| vascular process in circulatory system |
| cyclic-nucleotide-mediated signaling |
| female pregnancy |
| regulation of blood pressure |
| protein localization to plasma membrane |
| positive regulation of vasculature development |
| response to ketone |
| receptor complex |
| adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| multi-multicellular organism process |
| cell junction organization |
| protein localization to cell periphery |
| receptor-mediated endocytosis |
| muscle cell differentiation |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| calcium ion transport |
| lysosome |
| regulation of angiogenesis |
| divalent metal ion transport |
| divalent inorganic cation transport |
| angiogenesis |
| regulation of vasculature development |
| response to steroid hormone |
| second-messenger-mediated signaling |
| extracellular matrix organization |
| response to hypoxia |
| response to decreased oxygen levels |
| response to oxygen levels |
| extracellular structure organization |
| blood circulation |
| circulatory system process |
| blood vessel morphogenesis |
| muscle structure development |
| protein localization to membrane |
| blood vessel development |
| cellular response to growth factor stimulus |
| vasculature development |
| cardiovascular system development |
| heart development |
| response to growth factor |
| endocytosis |
| cellular response to hormone stimulus |
| cell surface |
| metal ion transport |
| tube morphogenesis |
| import into cell |
| cation transport |
| tube development |
| response to lipid |
| circulatory system development |
| negative regulation of apoptotic process |
| anatomical structure formation involved in morphogenesis |
| negative regulation of programmed cell death |
| response to hormone |
| response to organic cyclic compound |
| positive regulation of cell differentiation |
| negative regulation of cell death |
| multi-organism reproductive process |
| intracellular protein transport |
| response to drug |
| regulation of anatomical structure morphogenesis |
| response to abiotic stimulus |
| cellular response to endogenous stimulus |
| G protein-coupled receptor signaling pathway |
| positive regulation of developmental process |
| ion transport |
| integral component of plasma membrane |
| reproductive process |
| reproduction |
| response to endogenous stimulus |
| protein transport |
| intracellular transport |
| peptide transport |
| regulation of apoptotic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| cell development |
| regulation of cell death |
| intracellular signal transduction |
| positive regulation of multicellular organismal process |
| regulation of cell differentiation |
| establishment of localization in cell |
| nitrogen compound transport |
| vesicle-mediated transport |
| system process |
| positive regulation of gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 1/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2843
- Expression level (log2 read counts): -7.68
Expression Distribution
RAMP2 Expression in NALM6 Cells: -7.68
