RANBP9

Entrez Summary: N/A
UniProt Summary: May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA. {ECO:0000269|PubMed:12147692, ECO:0000269|PubMed:12361945, ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:14722085, ECO:0000269|PubMed:15381419, ECO:0000269|PubMed:15558019, ECO:0000269|PubMed:18222118}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

microtubule nucleation
microtubule associated complex
microtubule polymerization
Ran GTPase binding
microtubule polymerization or depolymerization
negative regulation of ERK1 and ERK2 cascade
protein polymerization
ubiquitin ligase complex
negative regulation of MAPK cascade
axon guidance
neuron projection guidance
regulation of ERK1 and ERK2 cascade
enzyme binding
axonogenesis
MAPK cascade
signal transduction by protein phosphorylation
negative regulation of protein phosphorylation
axon development
cell morphogenesis involved in neuron differentiation
negative regulation of phosphorylation
supramolecular fiber organization
microtubule cytoskeleton organization
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
negative regulation of intracellular signal transduction
cell part morphogenesis
chemotaxis
taxis
cell morphogenesis involved in differentiation
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
neuron projection development
microtubule-based process
cell morphogenesis
regulation of MAPK cascade
neuron development
cellular component morphogenesis
cellular protein-containing complex assembly