RANGRF

Gene Information

Official Symbol: RANGRF
Official Name: RAN guanine nucleotide release factor
Aliases and Previous Symbols: N/A
Entrez ID: 29098
UniProt: Q9HD47
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a protein that has been shown to function as a guanine nucleotide release factor in mouse and to regulate the expression and function of the Nav1.5 cardiac sodium channel in human. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010].
UniProt Summary: May regulate the intracellular trafficking of RAN (PubMed:11290418). Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1 (PubMed:29040603). Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics (PubMed:29040603). Enhances the expression of SCN5A at the cell membrane in cardiomyocytes (PubMed:18184654, PubMed:23420830, PubMed:21621375). {ECO:0000269|PubMed:11290418, ECO:0000269|PubMed:18184654, ECO:0000269|PubMed:21621375, ECO:0000269|PubMed:23420830, ECO:0000269|PubMed:29040603}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12064
Expression level (log2 read counts): 4.61

Expression Distribution

regulation of microtubule nucleation by Ran protein signal transduction
regulation of bundle of His cell action potential
Ran protein signal transduction
Ran guanyl-nucleotide exchange factor activity
regulation of membrane depolarization during cardiac muscle cell action potential
regulation of microtubule nucleation
regulation of membrane depolarization during action potential
regulation of cardiac muscle cell action potential involved in regulation of contraction
positive regulation of protein localization to cell surface
protein exit from endoplasmic reticulum
regulation of cardiac muscle cell action potential
sodium channel regulator activity
Ran GTPase binding
regulation of cardiac muscle cell contraction
regulation of protein localization to cell surface
regulation of actin filament-based movement
regulation of membrane depolarization
intercalated disc
regulation of action potential
regulation of microtubule polymerization
regulation of sodium ion transmembrane transporter activity
positive regulation of protein localization to plasma membrane
rough endoplasmic reticulum
positive regulation of protein localization to cell periphery
regulation of sodium ion transmembrane transport
regulation of cardiac conduction
caveola
regulation of cardiac muscle contraction
regulation of microtubule polymerization or depolymerization
regulation of sodium ion transport
regulation of striated muscle contraction
regulation of protein localization to plasma membrane
regulation of heart rate
guanyl-nucleotide exchange factor activity
regulation of protein localization to cell periphery
positive regulation of protein localization to membrane
ion channel binding
regulation of muscle contraction
regulation of protein localization to membrane
regulation of microtubule cytoskeleton organization