RAPGEF1

Gene Information

Official Symbol: RAPGEF1
Official Name: Rap guanine nucleotide exchange factor 1
Aliases and Previous Symbols: N/A
Entrez ID: 2889
UniProt: Q13905
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008].
UniProt Summary: Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth. {ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:7806500}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16140
Expression level (log2 read counts): 7.02

Expression Distribution

RasGEF N
RasGEF

positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis
Rap guanyl-nucleotide exchange factor activity
positive regulation of Fc receptor mediated stimulatory signaling pathway
regulation of Fc-gamma receptor signaling pathway involved in phagocytosis
Rap protein signal transduction
nerve growth factor signaling pathway
regulation of Fc receptor mediated stimulatory signaling pathway
negative regulation of neural precursor cell proliferation
neurotrophin signaling pathway
establishment of endothelial barrier
platelet-derived growth factor receptor signaling pathway
negative regulation of protein kinase B signaling
cellular response to nerve growth factor stimulus
endothelial cell development
response to nerve growth factor
negative regulation of Ras protein signal transduction
activation of MAPKK activity
cellular response to cAMP
negative regulation of small GTPase mediated signal transduction
positive regulation of Ras protein signal transduction
negative regulation of ERK1 and ERK2 cascade
positive regulation of phagocytosis
positive regulation of small GTPase mediated signal transduction
phagocytic vesicle membrane
endothelial cell differentiation
regulation of neural precursor cell proliferation
regulation of cell junction assembly
regulation of phagocytosis
endothelium development
activation of GTPase activity
response to cAMP
guanyl-nucleotide exchange factor activity
SH3 domain binding
response to organophosphorus
response to purine-containing compound
negative regulation of MAPK cascade
negative regulation of canonical Wnt signaling pathway
regulation of JNK cascade
epithelial cell development
negative regulation of Wnt signaling pathway