RARRES3

Gene Information

Official Symbol: PLAAT4
Official Name: phospholipase A and acyltransferase 4
Aliases and Previous Symbols: N/A
Entrez ID: 5920
UniProt: Q9UL19
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Exhibits PLA1/2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphotidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. N- and O-acylation activity is hardly detectable. {ECO:0000269|PubMed:19615464}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16761
Expression level (log2 read counts): -0.18

Expression Distribution

regulation of protein-glutamine gamma-glutamyltransferase activity
positive regulation of protein-glutamine gamma-glutamyltransferase activity
N-acylphosphatidylethanolamine metabolic process
1-acyl-2-lysophosphatidylserine acylhydrolase activity
phosphatidylserine 1-acylhydrolase activity
N-acyltransferase activity
phospholipase A1 activity
positive regulation of keratinocyte differentiation
phosphatidylethanolamine metabolic process
positive regulation of epidermal cell differentiation
phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)
phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
phosphatidylethanolamine acyl-chain remodeling
phospholipase A2 activity
positive regulation of epidermis development
regulation of keratinocyte differentiation
positive regulation of epithelial cell differentiation
regulation of epidermal cell differentiation
phosphatidylcholine metabolic process
regulation of epidermis development
regulation of epithelial cell differentiation
ammonium ion metabolic process
lipid catabolic process
glycerophospholipid metabolic process
phospholipid metabolic process
glycerolipid metabolic process
positive regulation of transferase activity
negative regulation of cell population proliferation
cellular amide metabolic process
organophosphate metabolic process
cellular lipid metabolic process
positive regulation of cell differentiation
regulation of transferase activity
lipid metabolic process
positive regulation of developmental process
positive regulation of catalytic activity
regulation of cell population proliferation
positive regulation of multicellular organismal process
organic substance catabolic process
positive regulation of molecular function