RARS [The Human Chemical-Genetic Interaction Map Project]

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======= RARS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RARS1
  * **<color #00a2e8>Official Name</color>**: arginyl-tRNA synthetase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5917|5917]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P54136|P54136]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RARS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RARS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/107820|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis (PubMed:25288775). Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1 (PubMed:17443684). {ECO:0000269|PubMed:17443684, ECO:0000269|PubMed:25288775}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DALR 1|
|tRNA-synt 1d|
|Arg tRNA synt N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|arginine-tRNA ligase activity|
|arginyl-tRNA aminoacylation|
|arginine binding|
|aminoacyl-tRNA synthetase multienzyme complex|
|tRNA aminoacylation for protein translation|
|tRNA aminoacylation|
|amino acid activation|
|tRNA binding|
|tRNA metabolic process|
|cellular amino acid metabolic process|
|cadherin binding|
|translation|
|peptide biosynthetic process|
|ncRNA metabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-2.3|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|-1.91|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-1.71|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|1.76|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|1.78|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|1.79|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|1.8|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|1.84|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.88|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|2.04|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.16|
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|2.25|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|2.37|
|[[:results:exp131|L-74142 5μM R03 exp131]]|2.57|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|2.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 21/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|2/26|
|breast|2/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|3/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|1/24|
|peripheral nervous system|2/16|
|plasma cell|0/15|
|prostate|1/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 533
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RARS Expression in NALM6 Cells: 6.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>