RARS

Entrez Summary: N/A
UniProt Summary: Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis (PubMed:25288775). Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1 (PubMed:17443684). {ECO:0000269|PubMed:17443684, ECO:0000269|PubMed:25288775}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Milciclib 2μM R08 exp502	-2.3
CCCP 0.1μM R00 exp10	-1.91
Ribavirin 10μM R01 exp52	-1.71
Oligomycin-A 20μM R00 exp26	1.76
YM155 0.001μM R08 exp432	1.78
Adefovir 20μM R07 exp332	1.79
Quinacrine 2.5μM R03 exp146	1.8
Pyronaridine 1μM R06 exp295	1.84
UM131593 0.2μM R03 exp106	1.88
OICR-9429 10μM R03 exp142	2.04
BI-6727 0.0125μM R03 exp97	2.16
Nicotinamide Riboside 100μM R03 exp139	2.25
GSK-LSD1 10μM R03 exp123	2.37
L-74142 5μM R03 exp131	2.57
SGC0649 7μM R03 exp150	2.8

Global Fraction of Cell Lines Where Essential: 21/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	2/26
breast	2/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	1/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	3/75
lymphocyte	0/16
ovary	1/26
pancreas	1/24
peripheral nervous system	2/16
plasma cell	0/15
prostate	1/1
skin	0/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Expression Distribution

arginine-tRNA ligase activity
arginyl-tRNA aminoacylation
arginine binding
aminoacyl-tRNA synthetase multienzyme complex
tRNA aminoacylation for protein translation
tRNA aminoacylation
amino acid activation
tRNA binding
tRNA metabolic process
cellular amino acid metabolic process
cadherin binding
translation
peptide biosynthetic process
ncRNA metabolic process
amide biosynthetic process
peptide metabolic process
cellular amide metabolic process
carboxylic acid metabolic process
oxoacid metabolic process
organic acid metabolic process
organonitrogen compound biosynthetic process
ATP binding
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
small molecule metabolic process
macromolecule biosynthetic process
membrane
gene expression