RASA4B

Entrez Summary: N/A
UniProt Summary: Ca(2+)-dependent Ras GTPase-activating protein, that may play a role in the Ras-MAPK pathway. {ECO:0000250|UniProtKB:O43374}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of Ras protein signal transduction
negative regulation of small GTPase mediated signal transduction
cellular response to calcium ion
phospholipid binding
response to calcium ion
cellular response to metal ion
cellular response to inorganic substance
regulation of Ras protein signal transduction
GTPase activator activity
regulation of small GTPase mediated signal transduction
response to metal ion
positive regulation of GTPase activity
regulation of GTPase activity
negative regulation of intracellular signal transduction
response to inorganic substance
positive regulation of hydrolase activity
negative regulation of signal transduction
regulation of hydrolase activity
negative regulation of cell communication
negative regulation of signaling
positive regulation of catalytic activity
negative regulation of response to stimulus
intracellular signal transduction
positive regulation of molecular function
regulation of intracellular signal transduction