RASD2

Entrez Summary: N/A
UniProt Summary: GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination. {ECO:0000269|PubMed:11976265, ECO:0000269|PubMed:19255495}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of protein sumoylation
synaptic transmission, dopaminergic
G-protein beta-subunit binding
regulation of protein sumoylation
phosphatidylinositol 3-kinase binding
ubiquitin conjugating enzyme binding
regulation of cAMP-mediated signaling
negative regulation of protein ubiquitination
negative regulation of protein modification by small protein conjugation or removal
positive regulation of protein modification by small protein conjugation or removal
positive regulation of protein kinase B signaling
locomotory behavior
regulation of protein ubiquitination
regulation of protein kinase B signaling
regulation of protein modification by small protein conjugation or removal
GTPase activity
GTP binding
chemical synaptic transmission
anterograde trans-synaptic signaling
trans-synaptic signaling
synaptic signaling
behavior
negative regulation of protein modification process
positive regulation of intracellular signal transduction
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
cell-cell signaling
positive regulation of protein modification process
positive regulation of cellular protein metabolic process
positive regulation of signal transduction
positive regulation of protein metabolic process
positive regulation of cell communication
positive regulation of signaling
regulation of intracellular signal transduction
regulation of protein modification process