RASSF2
Gene Information
- Official Symbol: RASSF2
- Official Name: Ras association domain family member 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 9770
- UniProt: P50749
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation. {ECO:0000269|PubMed:12732644, ECO:0000269|PubMed:16012945, ECO:0000269|PubMed:19525978}.
Pfam Domains GO Terms
Pfam Domains
| RA |
GO Terms
| epidermal growth factor receptor signaling pathway via positive regulation of NF-kappaB transcription factor activity |
| epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade |
| negative regulation of NIK/NF-kappaB signaling |
| positive regulation of protein autophosphorylation |
| negative regulation of peptidyl-serine phosphorylation |
| bone remodeling |
| regulation of protein autophosphorylation |
| epidermal growth factor receptor signaling pathway |
| regulation of osteoclast differentiation |
| ERBB signaling pathway |
| kinetochore |
| condensed chromosome kinetochore |
| tissue remodeling |
| regulation of NIK/NF-kappaB signaling |
| regulation of osteoblast differentiation |
| regulation of myeloid leukocyte differentiation |
| regulation of peptidyl-serine phosphorylation |
| positive regulation of JNK cascade |
| positive regulation of stress-activated MAPK cascade |
| positive regulation of stress-activated protein kinase signaling cascade |
| protein stabilization |
| regulation of JNK cascade |
| regulation of ossification |
| homeostasis of number of cells |
| regulation of myeloid cell differentiation |
| regulation of stress-activated MAPK cascade |
| regulation of stress-activated protein kinase signaling cascade |
| protein kinase activity |
| ossification |
| regulation of leukocyte differentiation |
| regulation of protein stability |
| negative regulation of protein phosphorylation |
| negative regulation of phosphorylation |
| regulation of hemopoiesis |
| skeletal system development |
| negative regulation of intracellular signal transduction |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| positive regulation of protein kinase activity |
| positive regulation of MAPK cascade |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| positive regulation of kinase activity |
| negative regulation of protein modification process |
| protein-containing complex |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| positive regulation of transferase activity |
| positive regulation of cell death |
| enzyme linked receptor protein signaling pathway |
| regulation of cellular response to stress |
| regulation of MAPK cascade |
| regulation of protein kinase activity |
| regulation of kinase activity |
| protein phosphorylation |
| regulation of transferase activity |
| Golgi apparatus |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| negative regulation of cellular protein metabolic process |
| positive regulation of phosphorylation |
| negative regulation of protein metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| phosphorylation |
| cell cycle |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of response to stress |
| regulation of apoptotic process |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| negative regulation of response to stimulus |
| homeostatic process |
| positive regulation of signal transduction |
| regulation of immune system process |
| regulation of cell death |
| positive regulation of protein metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15449
- Expression level (log2 read counts): 5.54
Expression Distribution
RASSF2 Expression in NALM6 Cells: 5.54
