RBM24
Gene Information
- Official Symbol: RBM24
- Official Name: RNA binding motif protein 24
- Aliases and Previous Symbols: N/A
- Entrez ID: 221662
- UniProt: Q9BX46
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Plays a role in myogenic differentiation by regulating MYOG levels. Binds to the 3'-UTR of MYOG mRNA and regulates its stability. {ECO:0000269|PubMed:20977548}.
Pfam Domains GO Terms
Pfam Domains
| RRM 1 |
GO Terms
| mRNA CDS binding |
| regulation of 3-UTR-mediated mRNA stabilization |
| positive regulation of 3-UTR-mediated mRNA stabilization |
| positive regulation of skeletal muscle fiber differentiation |
| regulation of skeletal muscle fiber differentiation |
| positive regulation of skeletal muscle cell differentiation |
| negative regulation of cytoplasmic translation |
| pre-mRNA intronic binding |
| sequence-specific mRNA binding |
| 3-UTR-mediated mRNA destabilization |
| regulation of skeletal muscle cell differentiation |
| positive regulation of stem cell differentiation |
| positive regulation of myoblast differentiation |
| positive regulation of skeletal muscle tissue development |
| mRNA 3-UTR AU-rich region binding |
| regulation of cytoplasmic translation |
| mRNA destabilization |
| RNA destabilization |
| positive regulation of myotube differentiation |
| endocardial cushion development |
| mRNA stabilization |
| RNA stabilization |
| positive regulation of mRNA catabolic process |
| regulation of skeletal muscle tissue development |
| negative regulation of mRNA catabolic process |
| regulation of myoblast differentiation |
| regulation of myotube differentiation |
| positive regulation of striated muscle cell differentiation |
| negative regulation of RNA catabolic process |
| regulation of alternative mRNA splicing, via spliceosome |
| positive regulation of muscle organ development |
| positive regulation of striated muscle tissue development |
| positive regulation of muscle tissue development |
| mRNA 3-UTR binding |
| positive regulation of mRNA metabolic process |
| negative regulation of mRNA metabolic process |
| positive regulation of muscle cell differentiation |
| regulation of mRNA splicing, via spliceosome |
| regulation of striated muscle cell differentiation |
| regulation of stem cell differentiation |
| negative regulation of translation |
| regulation of striated muscle tissue development |
| regulation of muscle tissue development |
| regulation of muscle organ development |
| regulation of RNA splicing |
| regulation of mRNA processing |
| negative regulation of cellular amide metabolic process |
| regulation of muscle cell differentiation |
| ribonucleoprotein complex |
| mRNA binding |
| regulation of mRNA stability |
| regulation of RNA stability |
| regulation of mRNA catabolic process |
| mesenchyme development |
| negative regulation of cellular catabolic process |
| negative regulation of catabolic process |
| regulation of mRNA metabolic process |
| regulation of translation |
| positive regulation of cellular catabolic process |
| RNA splicing |
| regulation of cellular amide metabolic process |
| positive regulation of catabolic process |
| mRNA processing |
| posttranscriptional regulation of gene expression |
| heart development |
| mRNA metabolic process |
| cellular response to DNA damage stimulus |
| regulation of cellular catabolic process |
| circulatory system development |
| RNA processing |
| positive regulation of cell differentiation |
| regulation of catabolic process |
| negative regulation of cellular protein metabolic process |
| negative regulation of protein metabolic process |
| negative regulation of RNA metabolic process |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| RNA binding |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| RNA metabolic process |
| cellular response to stress |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| regulation of cell differentiation |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of gene expression |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Rapamycin 2μM R07 exp306 | 1.94 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18129
- Expression level (log2 read counts): -2.28
Expression Distribution
RBM24 Expression in NALM6 Cells: -2.28
