RBM39 [The Human Chemical-Genetic Interaction Map Project]

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======= RBM39 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RBM39
  * **<color #00a2e8>Official Name</color>**: RNA binding motif protein 39
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9584|9584]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14498|Q14498]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RBM39&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RBM39|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604739|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the U2AF65 family of proteins. The encoded protein is found in the nucleus, where it co-localizes with core spliceosomal proteins. It has been shown to play a role in both steroid hormone receptor-mediated transcription and alternative splicing, and it is also a transcriptional coregulator of the viral oncoprotein v-Rel. Multiple transcript variants have been observed for this gene. A related pseudogene has been identified on chromosome X. [provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1 (By similarity). May be involved in pre-mRNA splicing process. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|microtubule cytoskeleton|
|microtubule organizing center|
|RNA splicing|
|nuclear speck|
|mRNA processing|
|protein-containing complex|
|mRNA metabolic process|
|RNA processing|
|RNA binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-2.39|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-2.37|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-2.22|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-1.94|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|-1.87|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-1.86|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-1.8|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-1.73|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|1.71|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|1.71|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|1.75|
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|1.77|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.81|
|[[:results:exp149|SB203580 25μM R03 exp149]]|1.82|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|1.94|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.95|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|1.97|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|2|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|2.02|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|2.06|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|2.1|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|2.12|
|[[:results:exp219|A-395N 10μM R05 exp219]]|2.13|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.15|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|2.19|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|2.22|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|2.24|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|2.25|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|2.25|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|2.32|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|2.36|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|2.37|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|2.38|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|2.85|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|3.09|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:narfl|NARFL]]|0.562|
|[[:human genes:c:cdc73|CDC73]]|0.558|
|[[:human genes:v:vasn|VASN]]|0.541|
|[[:human genes:r:rps12|RPS12]]|0.53|
|[[:human genes:s:supt6h|SUPT6H]]|0.524|
|[[:human genes:t:tfip11|TFIP11]]|0.519|
|[[:human genes:i:iscu|ISCU]]|0.511|
|[[:human genes:p:psmb4|PSMB4]]|0.509|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.507|
|[[:human genes:c:chd4|CHD4]]|0.503|
|[[:human genes:z:znf106|ZNF106]]|0.498|
|[[:human genes:t:tceb3c|TCEB3C]]|0.498|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.494|
|[[:human genes:r:rnf113a|RNF113A]]|0.494|
|[[:human genes:s:snrnp70|SNRNP70]]|0.492|
|[[:human genes:d:ddtl|DDTL]]|0.491|
|[[:human genes:c:copg1|COPG1]]|0.489|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.487|
|[[:human genes:d:dtl|DTL]]|0.487|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.486|
|[[:human genes:n:nol10|NOL10]]|0.484|
|[[:human genes:o:orc1|ORC1]]|0.483|
|[[:human genes:o:orc6|ORC6]]|0.483|
|[[:human genes:a:arcn1|ARCN1]]|0.482|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.481|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.481|
|[[:human genes:p:psmd14|PSMD14]]|0.481|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.48|
|[[:human genes:u:ubap1|UBAP1]]|0.48|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.48|
|[[:human genes:p:psma6|PSMA6]]|0.478|
|[[:human genes:p:psmd11|PSMD11]]|0.477|
|[[:human genes:a:akirin2|AKIRIN2]]|0.475|
|[[:human genes:r:rps28|RPS28]]|0.474|
|[[:human genes:g:gon4l|GON4L]]|0.474|
|[[:human genes:c:cdc6|CDC6]]|0.474|
|[[:human genes:m:myo1h|MYO1H]]|0.473|
|[[:human genes:s:sap30bp|SAP30BP]]|0.472|
|[[:human genes:t:ticrr|TICRR]]|0.469|
|[[:human genes:r:rrn3|RRN3]]|0.465|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.464|
|[[:human genes:c:c14orf93|C14orf93]]|0.464|
|[[:human genes:c:ctr9|CTR9]]|0.463|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.462|
|[[:human genes:m:mt1e|MT1E]]|0.462|
|[[:human genes:p:paf1|PAF1]]|0.461|
|[[:human genes:s:syt9|SYT9]]|0.459|
|[[:human genes:n:nup160|NUP160]]|0.459|
|[[:human genes:z:zfand5|ZFAND5]]|0.458|
|[[:human genes:o:or10g3|OR10G3]]|0.457|
|[[:human genes:p:psmb1|PSMB1]]|0.457|
|[[:human genes:p:psmc1|PSMC1]]|0.456|
|[[:human genes:r:rrp15|RRP15]]|0.456|
|[[:human genes:c:copz1|COPZ1]]|0.455|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.455|
|[[:human genes:t:traip|TRAIP]]|0.454|
|[[:human genes:s:sf3a1|SF3A1]]|0.452|
|[[:human genes:s:supt5h|SUPT5H]]|0.452|
|[[:human genes:g:golga8h|GOLGA8H]]|0.451|
|[[:human genes:c:cep192|CEP192]]|0.45|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.45|
|[[:human genes:r:rpl35|RPL35]]|0.449|
|[[:human genes:a:ankle2|ANKLE2]]|0.449|
|[[:human genes:c:copa|COPA]]|0.449|
|[[:human genes:p:psap|PSAP]]|0.447|
|[[:human genes:c:ckap5|CKAP5]]|0.446|
|[[:human genes:s:sf3a3|SF3A3]]|0.446|
|[[:human genes:c:cdca3|CDCA3]]|0.446|
|[[:human genes:r:rbbp5|RBBP5]]|0.444|
|[[:human genes:p:plk1|PLK1]]|0.444|
|[[:human genes:r:rps2|RPS2]]|0.443|
|[[:human genes:x:xylt2|XYLT2]]|0.443|
|[[:human genes:v:vps54|VPS54]]|0.441|
|[[:human genes:k:kctd17|KCTD17]]|0.441|
|[[:human genes:c:chmp2a|CHMP2A]]|0.441|
|[[:human genes:n:nfatc4|NFATC4]]|0.44|
|[[:human genes:n:nip7|NIP7]]|0.439|
|[[:human genes:p:pan3|PAN3]]|0.439|
|[[:human genes:s:sf3a2|SF3A2]]|0.438|
|[[:human genes:c:cactin|CACTIN]]|0.437|
|[[:human genes:i:ints6|INTS6]]|0.437|
|[[:human genes:s:scaf1|SCAF1]]|0.437|
|[[:human genes:p:psmc6|PSMC6]]|0.436|
|[[:human genes:s:smg7|SMG7]]|0.436|
|[[:human genes:c:cbwd3|CBWD3]]|0.436|
|[[:human genes:p:psmd1|PSMD1]]|0.435|
|[[:human genes:p:polr1a|POLR1A]]|0.434|
|[[:human genes:a:aamp|AAMP]]|0.432|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.432|
|[[:human genes:c:cmya5|CMYA5]]|0.431|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.431|
|[[:human genes:r:ranbp2|RANBP2]]|0.431|
|[[:human genes:r:rpl14|RPL14]]|0.431|
|[[:human genes:s:snip1|SNIP1]]|0.43|
|[[:human genes:g:gga3|GGA3]]|0.43|
|[[:human genes:r:rpa2|RPA2]]|0.429|
|[[:human genes:s:snrpa1|SNRPA1]]|0.428|
|[[:human genes:z:znf148|ZNF148]]|0.428|
|[[:human genes:i:ilf2|ILF2]]|0.428|
|[[:human genes:s:slc6a17|SLC6A17]]|0.428|
|[[:human genes:r:rpl38|RPL38]]|0.428|
|[[:human genes:m:mylk3|MYLK3]]|0.426|
|[[:human genes:a:aaas|AAAS]]|0.425|
|[[:human genes:a:atxn1|ATXN1]]|0.424|
|[[:human genes:n:napa|NAPA]]|0.424|
|[[:human genes:o:osbp|OSBP]]|0.423|
|[[:human genes:n:nupl1|NUPL1]]|0.423|
|[[:human genes:p:plk4|PLK4]]|0.423|
|[[:human genes:g:gosr2|GOSR2]]|0.422|
|[[:human genes:r:rps27a|RPS27A]]|0.422|
|[[:human genes:c:cgb2|CGB2]]|0.421|
|[[:human genes:r:rps14|RPS14]]|0.42|
|[[:human genes:f:fbxw9|FBXW9]]|0.42|
|[[:human genes:r:rnpc3|RNPC3]]|0.42|
|[[:human genes:p:pola2|POLA2]]|0.419|
|[[:human genes:p:prpf19|PRPF19]]|0.419|
|[[:human genes:s:stil|STIL]]|0.418|
|[[:human genes:c:chaf1a|CHAF1A]]|0.417|
|[[:human genes:i:ik|IK]]|0.417|
|[[:human genes:p:ppie|PPIE]]|0.417|
|[[:human genes:a:ahctf1|AHCTF1]]|0.417|
|[[:human genes:c:cope|COPE]]|0.416|
|[[:human genes:r:riok2|RIOK2]]|0.416|
|[[:human genes:c:cbwd5|CBWD5]]|0.415|
|[[:human genes:c:cbwd6|CBWD6]]|0.415|
|[[:human genes:b:brd2|BRD2]]|0.413|
|[[:human genes:e:egr2|EGR2]]|0.412|
|[[:human genes:k:kif3c|KIF3C]]|0.412|
|[[:human genes:s:ssh2|SSH2]]|0.412|
|[[:human genes:d:dnm2|DNM2]]|0.412|
|[[:human genes:t:tgm5|TGM5]]|0.411|
|[[:human genes:l:lad1|LAD1]]|0.411|
|[[:human genes:c:cwc22|CWC22]]|0.41|
|[[:human genes:f:fam25b|FAM25B]]|0.41|
|[[:human genes:e:elmod3|ELMOD3]]|0.41|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.408|
|[[:human genes:i:ints5|INTS5]]|0.407|
|[[:human genes:r:rpl34|RPL34]]|0.407|
|[[:human genes:e:exosc5|EXOSC5]]|0.407|
|[[:human genes:s:smg1|SMG1]]|0.407|
|[[:human genes:m:myh2|MYH2]]|0.407|
|[[:human genes:g:glcci1|GLCCI1]]|0.406|
|[[:human genes:p:prkcz|PRKCZ]]|0.406|
|[[:human genes:e:eif4a3|EIF4A3]]|0.405|
|[[:human genes:r:rps9|RPS9]]|0.405|
|[[:human genes:p:psma7|PSMA7]]|0.405|
|[[:human genes:n:nup54|NUP54]]|0.405|
|[[:human genes:g:golga8j|GOLGA8J]]|0.404|
|[[:human genes:s:smtn|SMTN]]|0.404|
|[[:human genes:w:wdr87|WDR87]]|0.402|
|[[:human genes:h:hnrnpa1|HNRNPA1]]|0.401|
|[[:human genes:s:sec13|SEC13]]|0.401|
|[[:human genes:f:fancm|FANCM]]|0.401|
|[[:human genes:h:hnrnpc|HNRNPC]]|0.4|
|[[:human genes:c:cyb561a3|CYB561A3]]|0.4|
|[[:human genes:g:gar1|GAR1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 673/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|26/28|
|blood|26/28|
|bone|24/26|
|breast|29/33|
|central nervous system|51/56|
|cervix|3/4|
|colorectal|14/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/16|
|kidney|17/21|
|liver|18/20|
|lung|65/75|
|lymphocyte|16/16|
|ovary|25/26|
|pancreas|22/24|
|peripheral nervous system|16/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|17/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|27/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 680
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RBM39 Expression in NALM6 Cells: 8.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>